9BKK

Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex

Summary for 9BKK

• Entry DOI: 10.2210/pdb9bkk/pdb
• EMDB information: 44643
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: cholecystokinin, gpcr, cholesterol, mutant, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 123256.99

Authors

Harikumar, K.G.,Zhao, P.,Cary, B.P.,Xu, X.,Desai, A.J.,Mobbs, J.I.,Toufaily, C.,Furness, S.G.B.,Christopoulos, A.,Belousoff, M.J.,Wootten, D.,Sexton, P.M.,Miller, L.J. (deposition date: 2024-04-29, release date: 2024-05-22)

• Primary citation: Harikumar, K.G.,Zhao, P.,Cary, B.P.,Xu, X.,Desai, A.J.,Mobbs, J.I.,Toufaily, C.,Furness, S.G.B.,Christopoulos, A.,Belousoff, M.J.,Wootten, D.,Sexton, P.M.,Miller, L.J.; Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.51 Å)