7TYH

Human Amylin2 Receptor in complex with Gs and human calcitonin peptide

Summary for 7TYH

Entry DOI	10.2210/pdb7tyh/pdb
EMDB information	26178 26179 26180 26184 26188 26190
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	amylin receptor, gpcr, ramp2, human calcitonin, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	7
Total formula weight	186965.22
Authors	Cao, J.,Belousoff, M.J.,Johnson, R.M.,Wootten, D.L.,Sexton, P.M. (deposition date: 2022-02-13, release date: 2022-03-23, Last modification date: 2022-04-06)
Primary citation	Cao, J.,Belousoff, M.J.,Liang, Y.L.,Johnson, R.M.,Josephs, T.M.,Fletcher, M.M.,Christopoulos, A.,Hay, D.L.,Danev, R.,Wootten, D.,Sexton, P.M. A structural basis for amylin receptor phenotype. Science, 375:eabm9609-eabm9609, 2022 Cited by PubMed: 35324283 DOI: 10.1126/science.abm9609 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation