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7TYH

Human Amylin2 Receptor in complex with Gs and human calcitonin peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
E0001525biological_processangiogenesis
E0001570biological_processvasculogenesis
E0001605molecular_functionadrenomedullin receptor activity
E0002040biological_processsprouting angiogenesis
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005886cellular_componentplasma membrane
E0005905cellular_componentclathrin-coated pit
E0006816biological_processcalcium ion transport
E0006886biological_processintracellular protein transport
E0007186biological_processG protein-coupled receptor signaling pathway
E0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
E0007507biological_processheart development
E0008217biological_processregulation of blood pressure
E0008277biological_processregulation of G protein-coupled receptor signaling pathway
E0009986cellular_componentcell surface
E0010628biological_processpositive regulation of gene expression
E0015026molecular_functioncoreceptor activity
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0031623biological_processreceptor internalization
E0032870biological_processcellular response to hormone stimulus
E0034333biological_processadherens junction assembly
E0035924biological_processcellular response to vascular endothelial growth factor stimulus
E0043116biological_processnegative regulation of vascular permeability
E0043235cellular_componentreceptor complex
E0045766biological_processpositive regulation of angiogenesis
E0070830biological_processbicellular tight junction assembly
E0070831biological_processbasement membrane assembly
E0072659biological_processprotein localization to plasma membrane
E0097084biological_processvascular associated smooth muscle cell development
E1903143cellular_componentadrenomedullin receptor complex
E1990409molecular_functionadrenomedullin binding
E1990410biological_processadrenomedullin receptor signaling pathway
E2000352biological_processnegative regulation of endothelial cell apoptotic process
E2001214biological_processpositive regulation of vasculogenesis
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
P0005179molecular_functionhormone activity
P0005576cellular_componentextracellular region
R0001503biological_processossification
R0001540molecular_functionamyloid-beta binding
R0001635molecular_functioncalcitonin gene-related peptide receptor activity
R0001669cellular_componentacrosomal vesicle
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004948molecular_functioncalcitonin receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0010628biological_processpositive regulation of gene expression
R0010739biological_processpositive regulation of protein kinase A signaling
R0016020cellular_componentmembrane
R0030279biological_processnegative regulation of ossification
R0030316biological_processosteoclast differentiation
R0030424cellular_componentaxon
R0032841molecular_functioncalcitonin binding
R0038041biological_processcross-receptor inhibition within G protein-coupled receptor heterodimer
R0043488biological_processregulation of mRNA stability
R0050850biological_processpositive regulation of calcium-mediated signaling
R0051384biological_processresponse to glucocorticoid
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0097643molecular_functionamylin receptor activity
R0097647biological_processamylin receptor signaling pathway
R0150056cellular_componentamylin receptor complex 1
R0150057cellular_componentamylin receptor complex 2
R0150058cellular_componentamylin receptor complex 3
R1904645biological_processresponse to amyloid-beta
Functional Information from PROSITE/UniProt
site_idPS00258
Number of Residues16
DetailsCALCITONIN Calcitonin / CGRP / IAPP family signature. CGNlSTCMlgtYtqdF
ChainResidueDetails
PCYS1-PHE16

site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWddTpagvlsyqfCP
ChainResidueDetails
RCYS72-PRO96

site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFVaTIYCFcNneV
ChainResidueDetails
RGLN383-VAL398

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues179
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
RALA25-ALA152
RASN208-ASN233
RTHR280-HIS296
RARG362-ASP373
AASP223
AASN292
ASER366

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RILE153-PHE173

site_idSWS_FT_FI3
Number of Residues116
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
RARG174-ASN186
RGLU255-ARG258
RASN318-LYS340
RASN395-ALA474

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RMET187-PRO207

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RTYR234-THR254

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RLEU259-ILE279

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RLEU297-LEU317

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RALA341-TRP361

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RTYR374-CYS394

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN28
RASN73
RASN125
RASN130

219515

PDB entries from 2024-05-08

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