7LLL

Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein

Summary for 7LLL

Entry DOI	10.2210/pdb7lll/pdb
EMDB information	23425
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	glucagon-like peptide-1 (glp-1) receptor, extendin-4, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	164298.07
Authors	Wootten, D.,Sexton, P.M.,Belousoff, M.J.,Danev, R.,Zhang, X.,Khoshouei, M.,Venugopal, H. (deposition date: 2021-02-04, release date: 2022-01-12, Last modification date: 2022-01-26)
Primary citation	Deganutti, G.,Liang, Y.L.,Zhang, X.,Khoshouei, M.,Clydesdale, L.,Belousoff, M.J.,Venugopal, H.,Truong, T.T.,Glukhova, A.,Keller, A.N.,Gregory, K.J.,Leach, K.,Christopoulos, A.,Danev, R.,Reynolds, C.A.,Zhao, P.,Sexton, P.M.,Wootten, D. Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13:92-92, 2022 Cited by PubMed: 35013280 DOI: 10.1038/s41467-021-27760-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation