7LLL
Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
Summary for 7LLL
Entry DOI | 10.2210/pdb7lll/pdb |
EMDB information | 23425 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | glucagon-like peptide-1 (glp-1) receptor, extendin-4, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 164298.07 |
Authors | Wootten, D.,Sexton, P.M.,Belousoff, M.J.,Danev, R.,Zhang, X.,Khoshouei, M.,Venugopal, H. (deposition date: 2021-02-04, release date: 2022-01-12, Last modification date: 2022-01-26) |
Primary citation | Deganutti, G.,Liang, Y.L.,Zhang, X.,Khoshouei, M.,Clydesdale, L.,Belousoff, M.J.,Venugopal, H.,Truong, T.T.,Glukhova, A.,Keller, A.N.,Gregory, K.J.,Leach, K.,Christopoulos, A.,Danev, R.,Reynolds, C.A.,Zhao, P.,Sexton, P.M.,Wootten, D. Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13:92-92, 2022 Cited by PubMed: 35013280DOI: 10.1038/s41467-021-27760-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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