7LLL
Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37413.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | N | Nb35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
5 | P | Exendin-4 | polymer | 39 | 4191.6 | 1 | UniProt (P26349) Pfam (PF00123) In PDB | Heloderma suspectum (Gila monster) | |
6 | R | Glucagon-like peptide 1 receptor | polymer | 491 | 56748.4 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (Human) | GLP-1R |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 24 - 463 (UniProt: P43220)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | conflict |
Ala 226 | Gly 226 | conflict |
Ala 268 | Glu 268 | conflict |
Lys 271 | Asn 271 | conflict |
Asp 274 | Lys 274 | conflict |
Lys 280 | Arg 280 | conflict |
Asp 284 | Thr 284 | conflict |
Thr 285 | Ile 285 | conflict |
PDB | External Database | Details |
---|---|---|
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -8 | - | expression tag |
Lys -7 | - | expression tag |
Thr -6 | - | expression tag |
Ile -5 | - | expression tag |
Ile -4 | - | expression tag |
Ala -3 | - | expression tag |
Leu -2 | - | expression tag |
Ser -1 | - | expression tag |
Tyr 0 | - | expression tag |
Ile 1 | - | expression tag |
Phe 2 | - | expression tag |
Cys 3 | - | expression tag |
Leu 4 | - | expression tag |
Val 5 | - | expression tag |
Phe 6 | - | expression tag |
Ala 7 | - | expression tag |
Asp 8 | - | expression tag |
Tyr 9 | - | expression tag |
Lys 10 | - | expression tag |
Asp 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Leu 15 | - | expression tag |
Glu 16 | - | expression tag |
Val 17 | - | expression tag |
Leu 18 | - | expression tag |
Phe 19 | - | expression tag |
Gln 20 | - | expression tag |
Gly 21 | - | expression tag |
Pro 22 | - | expression tag |
Ala 23 | - | expression tag |
Phe 260 | Leu 260 | conflict |
Pro 464 | - | expression tag |
Ala 465 | - | expression tag |
Gly 466 | - | expression tag |
Leu 467 | - | expression tag |
Glu 468 | - | expression tag |
Val 469 | - | expression tag |
Leu 470 | - | expression tag |
Phe 471 | - | expression tag |
Gln 472 | - | expression tag |
Gly 473 | - | expression tag |
Pro 474 | - | expression tag |
His 475 | - | expression tag |
His 476 | - | expression tag |
His 477 | - | expression tag |
His 478 | - | expression tag |
His 479 | - | expression tag |
His 480 | - | expression tag |
His 481 | - | expression tag |
His 482 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 164298.1 | |
All* | Total formula weight | 164298.1 |