6F0X
 
 | | Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20 | | 分子名称: | Cell division cycle protein 20 homolog, MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, ... | | 著者 | Alfieri, C, Chang, L, Barford, D. | | 登録日 | 2017-11-20 | | 公開日 | 2018-05-02 | | 最終更新日 | 2020-12-02 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.
Nature, 559, 2018
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8QRY
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1BZC
 | | HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI | | 分子名称: | 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) | | 著者 | Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D. | | 登録日 | 1998-10-27 | | 公開日 | 1999-02-16 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
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1BZH
 | | Cyclic peptide inhibitor of human PTP1B | | 分子名称: | PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) | | 著者 | Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D. | | 登録日 | 1998-10-28 | | 公開日 | 1999-02-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
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1A5Y
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1ABB
 | | CONTROL OF PHOSPHORYLASE B CONFORMATION BY A MODIFIED COFACTOR: CRYSTALLOGRAPHIC STUDIES ON R-STATE GLYCOGEN PHOSPHORYLASE RECONSTITUTED WITH PYRIDOXAL 5'-DIPHOSPHATE | | 分子名称: | GLYCOGEN PHOSPHORYLASE B, INOSINIC ACID, PYRIDOXAL-5'-DIPHOSPHATE, ... | | 著者 | Leonidas, D.D, Oikonomakos, N.G, Papageorgiou, A.C, Acharya, K.R, Barford, D, Johnson, L.N. | | 登録日 | 1992-04-09 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate.
Protein Sci., 1, 1992
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8Q84
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8QAU
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3ZJE
 | | A20 OTU domain in reversibly oxidised (SOH) state | | 分子名称: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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8Q85
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3ZJD
 | | A20 OTU domain in reduced, active state at 1.87 A resolution | | 分子名称: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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8S4G
 | | Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | 著者 | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | | 登録日 | 2024-02-21 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex
To Be Published
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4ADY
 | | Crystal structure of 26S proteasome subunit Rpn2 | | 分子名称: | 26S PROTEASOME REGULATORY SUBUNIT RPN2 | | 著者 | Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P. | | 登録日 | 2012-01-04 | | 公開日 | 2012-03-14 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
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3ZJF
 | | A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak. | | 分子名称: | A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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3ZJG
 | | A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak. | | 分子名称: | CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3 | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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1W9H
 | | The Structure of a Piwi protein from Archaeoglobus fulgidus. | | 分子名称: | CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ... | | 著者 | Parker, J.S, Roe, S.M, Barford, D. | | 登録日 | 2004-10-13 | | 公開日 | 2005-01-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
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6TGB
 | | CryoEM structure of the binary DOCK2-ELMO1 complex | | 分子名称: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | | 著者 | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | 登録日 | 2019-11-15 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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6TGC
 | | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | | 分子名称: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | 登録日 | 2019-11-15 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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6TLJ
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6TM5
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2JF5
 | | crystal structure of Lys63-linked di-ubiquitin | | 分子名称: | CADMIUM ION, CHLORIDE ION, COBALT (II) ION, ... | | 著者 | Komander, D, Odenwaelder, P, Barford, D. | | 登録日 | 2007-01-26 | | 公開日 | 2008-02-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
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1FQ1
 | | CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-DEPENDENT KINASE INHIBITOR 3, ... | | 著者 | Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. | | 登録日 | 2000-09-01 | | 公開日 | 2001-05-09 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
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1FPZ
 | | CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE | | 分子名称: | CYCLIN-DEPENDENT KINASE INHIBITOR 3, SULFATE ION | | 著者 | Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. | | 登録日 | 2000-09-01 | | 公開日 | 2001-05-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
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1B3U
 | | CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA | | 分子名称: | PROTEIN (PROTEIN PHOSPHATASE PP2A) | | 著者 | Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D. | | 登録日 | 1998-12-14 | | 公開日 | 1999-04-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
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1G1H
 | | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE | | 分子名称: | BI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE, PROTEIN TYROSINE PHOSPHATASE 1B | | 著者 | Salmeen, A, Andersen, J.N, Myers, M.P, Tonks, N.K, Barford, D. | | 登録日 | 2000-10-11 | | 公開日 | 2001-01-17 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
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