5WT9
| Complex structure of PD-1 and nivolumab-Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ... | 著者 | Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J. | 登録日 | 2016-12-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun, 8, 2017
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5GZO
| Structure of neutralizing antibody bound to Zika envelope protein | 分子名称: | Antibody heavy chain, Antibody light chain, Genome polyprotein | 著者 | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2016-09-29 | 公開日 | 2017-01-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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5GZN
| Structure of neutralizing antibody bound to Zika envelope protein | 分子名称: | Antibody Heavy chain, Antibody light chain, Genome polyprotein | 著者 | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2016-09-29 | 公開日 | 2016-12-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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5XJ3
| Complex structure of ipilimumab-scFv and CTLA-4 | 分子名称: | Cytotoxic T-lymphocyte protein 4, ipilimumab-VH, ipilimumab-VL | 著者 | He, M, Chai, Y, Qi, J, Tong, Z, Tan, S, Gao, G.F. | 登録日 | 2017-04-29 | 公開日 | 2018-04-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies Oncotarget, 8, 2017
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2FLR
| Novel 5-Azaindole Factor VIIa Inhibitors | 分子名称: | Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | 著者 | Riggs, J.R, Hu, H, Kolesnikov, A, Tong, Z, Leahy, E.M, Wesson, K.E, Shrader, W.D, Vijaykumar, D, Wahl, T.A, Sprengeler, P.A, Green, M.J, Yu, C, Katz, B.A, Young, W.B. | 登録日 | 2006-01-06 | 公開日 | 2007-01-23 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Novel 5-azaindole factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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7BZT
| Cryo-EM structure of mature Coxsackievirus A10 in complex with KRM1 at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP2, ... | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-04-28 | 公開日 | 2020-07-22 | 最終更新日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BZN
| Cryo-EM structure of mature Coxsackievirus A10 at pH 7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-04-28 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BZO
| Cryo-EM structure of mature Coxsackievirus A10 at pH 5.5 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-04-28 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BZU
| Cryo-EM structure of mature Coxsackievirus A10 in complex with KRM1 at pH 5.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP2, ... | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-04-28 | 公開日 | 2020-07-22 | 最終更新日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7C4Z
| Cryo-EM structure of empty Coxsackievirus A10 at pH 5.5 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-05-18 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7C4Y
| Cryo-EM structure of empty Coxsackievirus A10 at pH 7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-05-18 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7C4T
| Cryo-EM structure of A particle Coxsackievirus A10 at pH 7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-05-18 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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7C4W
| Cryo-EM structure of A particle Coxsackievirus A10 at pH 5.5 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J. | 登録日 | 2020-05-18 | 公開日 | 2020-07-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proc.Natl.Acad.Sci.USA, 117, 2020
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8HR1
| Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | 登録日 | 2022-12-14 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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8HQY
| Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | 分子名称: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | 著者 | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | 登録日 | 2022-12-14 | 公開日 | 2023-09-27 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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8HRD
| Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS74 Fab heavy chain, IMCAS74 Fab light chain, ... | 著者 | Zhao, R.C, Wu, L.L, Han, P. | 登録日 | 2022-12-15 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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6SF2
| Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3 | 著者 | Salmon, R.M, Guo, J, Yu, M, Li, W. | 登録日 | 2019-07-31 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
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6SF3
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6SF1
| Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). | 分子名称: | Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3 | 著者 | Salmon, R.M, Guo, J, Yu, M, Li, W. | 登録日 | 2019-07-30 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
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8IEJ
| RNF20-RNF40/hRad6A-Ub/nucleosome complex | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ... | 著者 | Ai, H, Deng, Z, Sun, M, Du, Y, Pan, M, Liu, L. | 登録日 | 2023-02-15 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
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8IEG
| Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase BRE1, Histone H2A type 1-B/E, ... | 著者 | Ai, H, Deng, Z, Pan, M, Liu, L. | 登録日 | 2023-02-15 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
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7Y3N
| Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, ... | 著者 | Rao, X, Chai, Y, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y3O
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, Light chain of BIOLS56, ... | 著者 | Rao, X, Gao, F, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7POJ
| Prodomain bound BMP10 crystal form 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 10, TETRAETHYLENE GLYCOL | 著者 | Guo, J, Yu, M, Li, W. | 登録日 | 2021-09-09 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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7POI
| Prodomain bound BMP10 crystal form 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 10, D(-)-TARTARIC ACID | 著者 | Guo, J, Yu, M, Li, W. | 登録日 | 2021-09-09 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
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