5GZN

Structure of neutralizing antibody bound to Zika envelope protein

Summary for 5GZN

Related5GZO
DescriptorGenome polyprotein, Antibody Heavy chain, Antibody light chain (3 entities in total)
Functional Keywordszika virus, human neutralizing antibody, envelope protein, molecular determinants, viral protein-immune system complex, viral protein/immune system
Biological sourceZika virus (ZIKV)
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Total number of polymer chains8
Total molecular weight272911.24
Authors
Primary citation
Wang, Q.,Yang, H.,Liu, X.,Dai, L.,Ma, T.,Qi, J.,Wong, G.,Peng, R.,Liu, S.,Li, J.,Li, S.,Song, J.,Liu, J.,He, J.,Yuan, H.,Xiong, Y.,Liao, Y.,Li, J.,Yang, J.,Tong, Z.,Griffin, B.D.,Bi, Y.,Liang, M.,Xu, X.,Qin, C.,Cheng, G.,Zhang, X.,Wang, P.,Qiu, X.,Kobinger, G.,Shi, Y.,Yan, J.,Gao, G.F.
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8:369ra179-369ra179, 2016
PubMed: 27974667 (PDB entries with the same primary citation)
DOI: 10.1126/scitranslmed.aai8336
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25960.0%6.0%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution