8HRD

Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab

Summary for 8HRD

Entry DOI	10.2210/pdb8hrd/pdb
Descriptor	Spike protein S1, IMCAS74 Fab heavy chain, IMCAS74 Fab light chain, ... (7 entities in total)
Functional Keywords	complex, viral protein, viral protein-immune system complex, viral protein/immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	20
Total formula weight	487973.09
Authors	Zhao, R.C.,Wu, L.L.,Han, P. (deposition date: 2022-12-15, release date: 2023-12-20, Last modification date: 2023-12-27)
Primary citation	Rao, X.,Zhao, R.,Tong, Z.,Guo, S.,Peng, W.,Liu, K.,Li, S.,Wu, L.,Tong, J.,Chai, Y.,Han, P.,Wang, F.,Jia, P.,Li, Z.,Zhao, X.,Li, D.,Zhang, R.,Zhang, X.,Zou, W.,Li, W.,Wang, Q.,Gao, G.F.,Wu, Y.,Dai, L.,Gao, F. Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120:e2314193120-e2314193120, 2023 Cited by PubMed: 38109549 DOI: 10.1073/pnas.2314193120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation