8HRD
Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P (A, B, K, T) | Spike protein S1 | polymer | 223 | 25194.4 | 4 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B, G, L, Q (O, C, L, W) | IMCAS74 Fab heavy chain | polymer | 235 | 25335.6 | 4 | Homo sapiens | ||
| 3 | C, H, M, R (P, E, M, X) | IMCAS74 Fab light chain | polymer | 217 | 22698.0 | 4 | Homo sapiens | ||
| 4 | D, I, N, S (D, G, N, Y) | W14 Fab heavy chain | polymer | 234 | 25102.1 | 4 | Homo sapiens | ||
| 5 | E, J, O, T (F, H, Q, Z) | W14 Fab light chain | polymer | 215 | 23441.9 | 4 | Homo sapiens | ||
| 6 | U, V, W, X (A, B, K, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | AA, BA, CA, DA, EA... (P, D, F, B, C...) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B, K, T: 319 - 541 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Arg 452 | Leu 452 | variant |
| Lys 478 | Thr 478 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 487088.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 487973.1 |
