2FLR
Novel 5-Azaindole Factor VIIa Inhibitors
Summary for 2FLR
Entry DOI | 10.2210/pdb2flr/pdb |
Related | 2FLB |
Descriptor | Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA, ... (5 entities in total) |
Functional Keywords | short hydrogen bond, 5-azaindole inhibitors, s1 site, hydrolase-blood clotting complex, hydrolase/blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726 |
Total number of polymer chains | 3 |
Total formula weight | 70248.06 |
Authors | Riggs, J.R.,Hu, H.,Kolesnikov, A.,Tong, Z.,Leahy, E.M.,Wesson, K.E.,Shrader, W.D.,Vijaykumar, D.,Wahl, T.A.,Sprengeler, P.A.,Green, M.J.,Yu, C.,Katz, B.A.,Young, W.B. (deposition date: 2006-01-06, release date: 2007-01-23, Last modification date: 2017-10-18) |
Primary citation | Riggs, J.R.,Hu, H.,Kolesnikov, A.,Leahy, E.M.,Wesson, K.E.,Shrader, W.D.,Vijaykumar, D.,Wahl, T.A.,Tong, Z.,Sprengeler, P.A.,Green, M.J.,Yu, C.,Katz, B.A.,Sanford, E.,Nguyen, M.,Cabuslay, R.,Young, W.B. Novel 5-azaindole factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 16:3197-3200, 2006 Cited by PubMed: 16621549DOI: 10.1016/j.bmcl.2006.03.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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