6SF2

Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1).

Summary for 6SF2

• Entry DOI: 10.2210/pdb6sf2/pdb
• Related: 6SF1 6SF3
• Descriptor: Serine/threonine-protein kinase receptor R3, Growth/differentiation factor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: bmp9, alk1, prodomain, ternary complex, signalling, tgfbeta, bmp, cytokine
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 112434.24

Authors

Salmon, R.M.,Guo, J.,Yu, M.,Li, W. (deposition date: 2019-07-31, release date: 2020-04-08, Last modification date: 2024-01-24)

• Primary citation: Salmon, R.M.,Guo, J.,Wood, J.H.,Tong, Z.,Beech, J.S.,Lawera, A.,Yu, M.,Grainger, D.J.,Reckless, J.,Morrell, N.W.,Li, W.; Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.; Nat Commun, 11:1621-1621, 2020; PubMed: 32238803; DOI: 10.1038/s41467-020-15425-3

Experimental method

X-RAY DIFFRACTION (3.3 Å)