6P9U
 
 | | Crystal structure of human thrombin mutant W215A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, ZINC ION | | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Di Cera, E. | | 登録日 | 2019-06-10 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
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6PX5
 | | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | | 登録日 | 2019-07-24 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
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4NZQ
 | | Crystal structure of Ca2+-free prothrombin deletion mutant residues 146-167 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | | 著者 | Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E. | | 登録日 | 2013-12-12 | | 公開日 | 2014-05-21 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.807 Å) | | 主引用文献 | The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4RN6
 | | Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban | | 分子名称: | (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, Thrombin heavy chain | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Niu, W, Barranco-Medina, S, Pelc, L.A, Di Cera, E. | | 登録日 | 2014-10-23 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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4O03
 | | Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin | | 著者 | Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E. | | 登録日 | 2013-12-13 | | 公開日 | 2014-05-21 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | | 主引用文献 | The linker connecting the two kringles plays a key role in prothrombin activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3NXP
 | | Crystal structure of human prethrombin-1 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Chen, Z, Bush-Pelc, L.A, Di Cera, E. | | 登録日 | 2010-07-14 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of prethrombin-1.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8FDG
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8TN9
 | | Structural architecture of the acidic region of the B domain of coagulation factor V | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor V | | 著者 | Mohammed, B.M, Basore, K, Summers, B, Pelc, L.A, Di Cera, E. | | 登録日 | 2023-08-01 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural architecture of the acidic region of the B domain of coagulation factor V.
J.Thromb.Haemost., 22, 2024
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6PXQ
 | | Crystal structure of human thrombin mutant D194A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | | 登録日 | 2019-07-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold.
Sci Rep, 9, 2019
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6PXJ
 | | Crystal structure of human thrombin mutant I16T | | 分子名称: | GLYCEROL, MAGNESIUM ION, Thrombin heavy chain, ... | | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | | 登録日 | 2019-07-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold.
Sci Rep, 9, 2019
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2PV9
 | | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 4, Thrombin heavy chain, ... | | 著者 | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-05-09 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2PUX
 | | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 3, Thrombin heavy chain, ... | | 著者 | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-05-09 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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3JZ1
 | | Crystal structure of human thrombin mutant N143P in E:Na+ form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NITRATE ION, ... | | 著者 | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | | 登録日 | 2009-09-22 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Mutant N143P reveals how Na+ activates thrombin
J.Biol.Chem., 284, 2009
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3JZ2
 | | Crystal structure of human thrombin mutant N143P in E* form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ... | | 著者 | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | | 登録日 | 2009-09-22 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Mutant N143P reveals how Na+ activates thrombin
J.Biol.Chem., 284, 2009
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2PGQ
 | | Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-04-10 | | 公開日 | 2007-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
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2PGB
 | | Inhibitor-free human thrombin mutant C191A-C220A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, SULFATE ION | | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-04-09 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
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4H6S
 | | Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A | | 分子名称: | Prothrombin, SODIUM ION | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-09-19 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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4H6T
 | | Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A | | 分子名称: | PHOSPHATE ION, Prothrombin | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-09-19 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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4HFP
 | | Structure of thrombin mutant S195a bound to the active site inhibitor argatroban | | 分子名称: | (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, Prothrombin, SODIUM ION | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Lin, W, Barranco-Medina, S, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-10-05 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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4RKJ
 | | Crystal structure of thrombin mutant S195T (free form) | | 分子名称: | GLYCEROL, POTASSIUM ION, Thrombin heavy chain, ... | | 著者 | Pelc, A.L, Chen, Z, Gohara, D.W, Vogt, A.D, Pozzi, N, Di Cera, E. | | 登録日 | 2014-10-13 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Why ser and not thr brokers catalysis in the trypsin fold.
Biochemistry, 54, 2015
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4RKO
 | | Crystal structure of thrombin mutant S195T bound with PPACK | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | | 著者 | Pelc, A.L, Chen, Z, Gohara, D.W, Vogt, A.D, Pozzi, N, Di Cera, E. | | 登録日 | 2014-10-13 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Why ser and not thr brokers catalysis in the trypsin fold.
Biochemistry, 54, 2015
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7SR9
 | | Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | | 著者 | Di Cera, E, Ruben, E.A, Chen, Z. | | 登録日 | 2021-11-08 | | 公開日 | 2021-12-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The active site region plays a critical role in Na + binding to thrombin.
J.Biol.Chem., 298, 2022
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2OD3
 | | Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2006-12-21 | | 公開日 | 2007-04-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin.
J.Biol.Chem., 282, 2007
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2OCV
 | | Structural basis of Na+ activation mimicry in murine thrombin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin | | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2006-12-21 | | 公開日 | 2007-04-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin.
J.Biol.Chem., 282, 2007
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6BJR
 | | Crystal structure of prothrombin mutant S101C/A470C | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... | | 著者 | Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. | | 登録日 | 2017-11-06 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
Sci Rep, 8, 2018
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