2OD3

Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents.

Summary for 2OD3

• Entry DOI: 10.2210/pdb2od3/pdb
• Related: 1SHH
• Related PRD ID: PRD_000020
• Descriptor: Thrombin light chain, Thrombin heavy chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (5 entities in total)
• Functional Keywords: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 34581.09

Authors

Marino, F.,Chen, Z.,Ergenekan, C.E.,Bush, L.A.,Mathews, F.S.,Di Cera, E. (deposition date: 2006-12-21, release date: 2007-04-10, Last modification date: 2024-03-13)

• Primary citation: Marino, F.,Chen, Z.W.,Ergenekan, C.E.,Bush-Pelc, L.A.,Mathews, F.S.,Di Cera, E.; Structural basis of na+ activation mimicry in murine thrombin.; J.Biol.Chem., 282:16355-16361, 2007; PubMed: 17428793; DOI: 10.1074/jbc.M701323200

Experimental method

X-RAY DIFFRACTION (1.75 Å)