2OD3
Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombin light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (B) | Thrombin heavy chain | polymer | 259 | 29809.4 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (B) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Phe 184 | Tyr 553 | engineered mutation |
| Val 186 | Pro 555 | engineered mutation |
| Asn 186 | Asp 556 | engineered mutation |
| Asp 186 | Glu 557 | engineered mutation |
| Thr 186 | Gly 558 | engineered mutation |
| Lys 222 | Asp 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33905.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 675.2 | |
| All* | Total formula weight | 34581.1 |
