4RKJ
Crystal structure of thrombin mutant S195T (free form)
Summary for 4RKJ
Entry DOI | 10.2210/pdb4rkj/pdb |
Related | 1SHH 4RKO |
Descriptor | Thrombin light chain, Thrombin heavy chain, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | trypsin-like proteases, catalysis, allosteric regulation, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 2 |
Total formula weight | 33957.88 |
Authors | Pelc, A.L.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E. (deposition date: 2014-10-13, release date: 2015-03-11, Last modification date: 2023-09-20) |
Primary citation | Pelc, L.A.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E. Why ser and not thr brokers catalysis in the trypsin fold. Biochemistry, 54:1457-1464, 2015 Cited by PubMed: 25664608DOI: 10.1021/acs.biochem.5b00014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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