3A8E
| The structure of AxCesD octamer complexed with cellopentaose | 分子名称: | Cellulose synthase operon protein D, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Hu, S.Q, Tajima, K, Zhou, Y, Yao, M, Tanaka, I. | 登録日 | 2009-10-05 | 公開日 | 2010-09-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of bacterial cellulose synthase subunit D octamer with four inner passageways Proc.Natl.Acad.Sci.USA, 107, 2010
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3AJ2
| The structure of AxCeSD octamer (C-terminal HIS-tag) from Acetobacter xylinum | 分子名称: | Cellulose synthase operon protein D | 著者 | Hu, S.Q, Tajima, K, Zhou, Y, Tanaka, I, Yao, M. | 登録日 | 2010-05-20 | 公開日 | 2010-10-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of bacterial cellulose synthase subunit D octamer with four inner passageways Proc.Natl.Acad.Sci.USA, 107, 2010
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3AJ1
| The structure of AxCeSD octamer (N-terminal HIS-tag) from Acetobacter xylinum | 分子名称: | Cellulose synthase operon protein D | 著者 | Hu, S.Q, Tajima, K, Zhou, Y, Tanaka, I, Yao, M. | 登録日 | 2010-05-20 | 公開日 | 2010-10-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of bacterial cellulose synthase subunit D octamer with four inner passageways Proc.Natl.Acad.Sci.USA, 107, 2010
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5ZVL
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1RWE
| Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2003-12-16 | 公開日 | 2005-02-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry, 43, 2004
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3V19
| Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | 登録日 | 2011-12-09 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health To be Published
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3V1G
| Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | 登録日 | 2011-12-09 | 公開日 | 2012-12-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health To be Published
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3BXQ
| The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition | 分子名称: | ZINC ION, insulin A chain, insulin B chain | 著者 | Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. | 登録日 | 2008-01-14 | 公開日 | 2008-05-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008
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3P2X
| Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2010-10-04 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity To be Published
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3P33
| Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2010-10-04 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity To be Published
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3JSD
| Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | 登録日 | 2009-09-10 | 公開日 | 2010-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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3KQ6
| Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | 登録日 | 2009-11-17 | 公開日 | 2010-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
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3ROV
| Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | 登録日 | 2011-04-26 | 公開日 | 2012-05-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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1T1K
| NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | 分子名称: | Insulin | 著者 | Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2004-04-16 | 公開日 | 2004-08-10 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor. J.Mol.Biol., 341, 2004
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1T1Q
| NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | 分子名称: | Insulin, insulin | 著者 | Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2004-04-16 | 公開日 | 2004-08-10 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor. J.Mol.Biol., 341, 2004
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1T1P
| NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | 分子名称: | Insulin, insulin | 著者 | Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2004-04-16 | 公開日 | 2004-08-10 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor. J.Mol.Biol., 341, 2004
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1SJT
| MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES | 分子名称: | PROINSULIN | 著者 | Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1997-10-09 | 公開日 | 1998-03-18 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures. J.Mol.Biol., 277, 1998
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1SJU
| MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES | 分子名称: | PROINSULIN | 著者 | Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1997-10-09 | 公開日 | 1998-03-18 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures. J.Mol.Biol., 277, 1998
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1VKT
| HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES | 分子名称: | INSULIN | 著者 | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1996-10-14 | 公開日 | 1997-04-01 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J.Mol.Biol., 264, 1996
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1XW7
| Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Wan, Z.L, Huang, K, Xu, B, Chu, Y.C, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2004-10-29 | 公開日 | 2005-04-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama Biochemistry, 44, 2005
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5XWF
| Crystal structure of chitinase (RmChi1) from Rhizomucor miehei (SP3221/SAD) | 分子名称: | Fungal chitinase from Rhizomucor miehei (SeMet-substituted proteins) | 著者 | Jiang, Z.Q, Hu, S.Q, Liu, Y.C, Qin, Z, Yan, Q.J, Yang, S.Q. | 登録日 | 2017-06-29 | 公開日 | 2018-07-04 | 最終更新日 | 2021-08-18 | 実験手法 | X-RAY DIFFRACTION (2.581 Å) | 主引用文献 | Crystal structure of a chitinase (RmChiA) from the thermophilic fungus Rhizomucor miehei with a real active site tunnel. Biochim Biophys Acta Proteins Proteom, 2021
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2H67
| NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Hua, Q.X, Liu, M, Hu, S.Q, Jia, W, Arvan, P, Weiss, M.A. | 登録日 | 2006-05-30 | 公開日 | 2006-07-18 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog. J.Biol.Chem., 281, 2006
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2HH4
| NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | 分子名称: | insulin A chain, insulin B chain | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | 登録日 | 2006-06-27 | 公開日 | 2006-07-18 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain. J.Biol.Chem., 281, 2006
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2HHO
| NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | 登録日 | 2006-06-28 | 公開日 | 2006-07-18 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain. J.Biol.Chem., 281, 2006
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2JZQ
| Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures | 分子名称: | Insulin | 著者 | Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A. | 登録日 | 2008-01-11 | 公開日 | 2008-02-26 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J.Biol.Chem., 283, 2008
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