2LK3
| U2/U6 Helix I | 分子名称: | RNA (5'-R(*GP*GP*CP*UP*UP*AP*GP*AP*UP*CP*AP*GP*AP*AP*AP*UP*GP*AP*UP*CP*AP*GP*CP*C)-3') | 著者 | Burke, J.E, Sashital, D.G, Zuo, X.E, Wang, Y, Butcher, S.E. | 登録日 | 2011-10-03 | 公開日 | 2012-02-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the yeast U2/U6 snRNA complex. Rna, 18, 2012
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2LKR
| Yeast U2/U6 complex | 分子名称: | RNA (111-MER) | 著者 | Burke, J.E, Sashital, D.G, Zuo, X, Wang, Y, Butcher, S.E. | 登録日 | 2011-10-19 | 公開日 | 2012-02-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the yeast U2/U6 snRNA complex. Rna, 18, 2012
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4D0M
| Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... | 著者 | Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughlin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. | 登録日 | 2014-04-29 | 公開日 | 2014-05-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science, 344, 2014
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4D0L
| Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... | 著者 | Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. | 登録日 | 2014-04-29 | 公開日 | 2014-05-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science, 344, 2014
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8AJ8
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8DP0
| Structure of p110 gamma bound to the Ras inhibitory nanobody NB7 | 分子名称: | Nanobody NB7, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Burke, J.E, Nam, S.E, Rathinaswamy, M.K, Yip, C.K. | 登録日 | 2022-07-14 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Allosteric activation or inhibition of PI3K gamma mediated through conformational changes in the p110 gamma helical domain. Elife, 12, 2023
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7R9V
| Structure of PIK3CA with covalent inhibitor 19 | 分子名称: | N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-1-(prop-2-enoyl)piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Burke, J.E, McPhail, J.A. | 登録日 | 2021-06-29 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha. J.Am.Chem.Soc., 144, 2022
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7R9Y
| Structure of PIK3CA with covalent inhibitor 22 | 分子名称: | N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Burke, J.E, McPhail, J.A. | 登録日 | 2021-06-29 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha. J.Am.Chem.Soc., 144, 2022
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6OAC
| PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha | 分子名称: | 4-(difluoromethyl)-5-{4-[(3S)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Burke, J.E, McPhail, J.A. | 登録日 | 2019-03-15 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J.Med.Chem., 62, 2019
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7MEZ
| Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5 | 著者 | Burke, J.E, Dalwadi, U, Rathinaswamy, M.K, Yip, C.K. | 登録日 | 2021-04-08 | 公開日 | 2021-07-14 | 最終更新日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation. Sci Adv, 7, 2021
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5JHB
| Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin3 | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol | 著者 | Burke, J.E, Inglis, A.J, Williams, R.L. | 登録日 | 2016-04-20 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8, 2017
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5JHA
| Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin2 | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol | 著者 | Burke, J.E, Inglis, A.J, Williams, R.L. | 登録日 | 2016-04-20 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8, 2017
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6DJL
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5C46
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5C4G
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7JX0
| NVS-PI3-4 bound to the PI3Kg catalytic subunit p110 gamma | 分子名称: | N~3~-{[5-(4-acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoyl}-N-tert-butyl-beta-alaninamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Burke, J.E, Rathinaswamy, M.K, Harris, N.J. | 登録日 | 2020-08-26 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10, 2021
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7JWZ
| IPI-549 bound to the PI3Kg catalytic subunit p110 gamma | 分子名称: | 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Burke, J.E, Rathinaswamy, M.K, Harris, N.J. | 登録日 | 2020-08-26 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10, 2021
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7JWE
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5EUQ
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2N7M
| NMR-SAXS/WAXS Structure of the core of the U4/U6 di-snRNA | 分子名称: | RNA (92-MER) | 著者 | Cornilescu, G, Didychuk, A.L, Rodgers, M.L, Michael, L.A, Burke, J.E, Montemayor, E.J, Hoskins, A.A, Butcher, S.E, Tonelli, M. | 登録日 | 2015-09-14 | 公開日 | 2015-12-30 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA. J.Mol.Biol., 428, 2016
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2N8V
| An NMR/SAXS structure of the PKI domain of the honeybee dicistrovirus, Israeli acute paralysis virus (IAPV) IRES | 分子名称: | RNA (70-MER) | 著者 | Au, H.H, Cornilescu, G, Mouzakis, K.D, Burke, J.E, Ren, Q, Lee, S, Butcher, S.E, Jan, E. | 登録日 | 2015-10-27 | 公開日 | 2015-11-11 | 最終更新日 | 2016-01-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection. Proc.Natl.Acad.Sci.USA, 112, 2015
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6ARK
| Crystal Structure of compound 10 covalently bound to K-Ras G12C | 分子名称: | (3R)-N-(6-bromonaphthalen-2-yl)-3-hydroxy-1-propanoyl-L-prolinamide, GLYCEROL, GTPase KRas, ... | 著者 | Nnadi, C.I, Jenkins, M.L, Gentile, D.R, Bateman, L.A, Zaidman, D, Balius, T.E, Nomura, D.K, Burke, J.E, Shokat, K.M, London, N. | 登録日 | 2017-08-22 | 公開日 | 2018-01-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model, 58, 2018
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5LRV
| Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ... | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | 登録日 | 2016-08-22 | 公開日 | 2016-10-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature, 538, 2016
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5LRW
| Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | 登録日 | 2016-08-22 | 公開日 | 2016-10-19 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature, 538, 2016
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5LRU
| Structure of Cezanne/OTUD7B OTU domain | 分子名称: | OTU domain-containing protein 7B | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | 登録日 | 2016-08-22 | 公開日 | 2016-10-19 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature, 538, 2016
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