7MEZ

Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex

Summary for 7MEZ

• Entry DOI: 10.2210/pdb7mez/pdb
• EMDB information: 23808
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5 (2 entities in total)
• Functional Keywords: pi3k, p110, pik3cg, pik3r5, p101, phosphoinositide 3-kinase, pip3, immune system, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 224099.21

Authors

Burke, J.E.,Dalwadi, U.,Rathinaswamy, M.K.,Yip, C.K. (deposition date: 2021-04-08, release date: 2021-07-14, Last modification date: 2022-04-06)

• Primary citation: Rathinaswamy, M.K.,Dalwadi, U.,Fleming, K.D.,Adams, C.,Stariha, J.T.B.,Pardon, E.,Baek, M.,Vadas, O.,DiMaio, F.,Steyaert, J.,Hansen, S.D.,Yip, C.K.,Burke, J.E.; Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation.; Sci Adv, 7:-, 2021; PubMed: 34452907; DOI: 10.1126/sciadv.abj4282

Experimental method

ELECTRON MICROSCOPY (2.89 Å)