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7MEZ

Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0001819biological_processpositive regulation of cytokine production
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0002407biological_processdendritic cell chemotaxis
A0002679biological_processrespiratory burst involved in defense response
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
A0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
A0006629biological_processlipid metabolic process
A0006897biological_processendocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007186biological_processG protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0010595biological_processpositive regulation of endothelial cell migration
A0010818biological_processT cell chemotaxis
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0016477biological_processcell migration
A0016740molecular_functiontransferase activity
A0030593biological_processneutrophil chemotaxis
A0033628biological_processregulation of cell adhesion mediated by integrin
A0035005molecular_function1-phosphatidylinositol-4-phosphate 3-kinase activity
A0035022biological_processpositive regulation of Rac protein signal transduction
A0035747biological_processnatural killer cell chemotaxis
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042802molecular_functionidentical protein binding
A0043303biological_processmast cell degranulation
A0043406biological_processpositive regulation of MAP kinase activity
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0045087biological_processinnate immune response
A0045765biological_processregulation of angiogenesis
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0046875molecular_functionephrin receptor binding
A0046934molecular_function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A0048015biological_processphosphatidylinositol-mediated signaling
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055118biological_processnegative regulation of cardiac muscle contraction
A0070527biological_processplatelet aggregation
A0072672biological_processneutrophil extravasation
A0106310molecular_functionprotein serine kinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005942cellular_componentphosphatidylinositol 3-kinase complex
B0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0043406biological_processpositive regulation of MAP kinase activity
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0046935molecular_function1-phosphatidylinositol-3-kinase regulator activity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
ChainResidueDetails
APHE832-GLN846

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
ChainResidueDetails
ASER931-ASN951

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues182
DetailsDomain: {"description":"PIK helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00878","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues283
DetailsDomain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues26
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues25
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"UniProtKB","id":"Q9JHG7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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