7MEZ
Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 1102 | 126627.4 | 1 | UniProt (P48736) Pfam (PF19710) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (Human) | PI3-kinase subunit gamma,PI3K-gamma,PI3Kgamma,PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,PtdIns-3-kinase subunit p110-gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p120-PI3K |
| 2 | B (B) | Phosphoinositide 3-kinase regulatory subunit 5 | polymer | 881 | 97471.8 | 1 | UniProt (O02696) Pfam (PF10486) | Sus scrofa (Pig) | PI3-kinase regulatory subunit 5,IB PI3-kinase p101 subunit,PI3-kinase p101 subunit,Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit,PtdIns-3-kinase regulatory subunit,PtdIns-3-kinase p101,p101-PI3K |
Sequence modifications
B: 1 - 877 (UniProt: O02696)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Arg 473 | Gly 473 | engineered mutation |
| Ala 530 | Val 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 224099.2 | |
| All* | Total formula weight | 224099.2 |
