7JWE

Gedatolisib bound to the PI3Kg catalytic subunit p110 gamma

Summary for 7JWE

Entry DOI	10.2210/pdb7jwe/pdb
Related	5JHA
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Gedatolisib (3 entities in total)
Functional Keywords	pik3cg, mtor, phosphoinositide, pip3, pi3k, p110, signaling protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	111342.83
Authors	Burke, J.E.,Rathinaswamy, M.K.,Harris, N.J. (deposition date: 2020-08-25, release date: 2021-03-17, Last modification date: 2023-10-18)
Primary citation	Rathinaswamy, M.K.,Gaieb, Z.,Fleming, K.D.,Borsari, C.,Harris, N.J.,Moeller, B.J.,Wymann, M.P.,Amaro, R.E.,Burke, J.E. Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10:-, 2021 Cited by PubMed: 33661099 DOI: 10.7554/eLife.64691 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation