7JWZ

IPI-549 bound to the PI3Kg catalytic subunit p110 gamma

Summary for 7JWZ

• Entry DOI: 10.2210/pdb7jwz/pdb
• Related: 7JWE
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (2 entities in total)
• Functional Keywords: pi3k, inhibitor, phosphoinositides, p110, pik3cg, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 111255.67

Authors

Burke, J.E.,Rathinaswamy, M.K.,Harris, N.J. (deposition date: 2020-08-26, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Rathinaswamy, M.K.,Gaieb, Z.,Fleming, K.D.,Borsari, C.,Harris, N.J.,Moeller, B.J.,Wymann, M.P.,Amaro, R.E.,Burke, J.E.; Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.; Elife, 10:-, 2021; PubMed: 33661099; DOI: 10.7554/eLife.64691

Experimental method

X-RAY DIFFRACTION (2.65 Å)