5JHA
Structure of Phosphoinositide 3-kinase gamma (PI3K) bound to the potent inhibitor PIKin2
Summary for 5JHA
Entry DOI | 10.2210/pdb5jha/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, lipid kinase, pi3k, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110741.32 |
Authors | Burke, J.E.,Inglis, A.J.,Williams, R.L. (deposition date: 2016-04-20, release date: 2017-03-15, Last modification date: 2024-01-10) |
Primary citation | Bohnacker, T.,Prota, A.E.,Beaufils, F.,Burke, J.E.,Melone, A.,Inglis, A.J.,Rageot, D.,Sele, A.M.,Cmiljanovic, V.,Cmiljanovic, N.,Bargsten, K.,Aher, A.,Akhmanova, A.,Diaz, J.F.,Fabbro, D.,Zvelebil, M.,Williams, R.L.,Steinmetz, M.O.,Wymann, M.P. Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nat Commun, 8:14683-14683, 2017 Cited by PubMed: 28276440DOI: 10.1038/ncomms14683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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