6ARK

Crystal Structure of compound 10 covalently bound to K-Ras G12C

Summary for 6ARK

Entry DOI	10.2210/pdb6ark/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	dockovalent, covalent docking, k-ras g12c, covalent inhibitors, covalent fragments, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20395.74
Authors	Nnadi, C.I.,Jenkins, M.L.,Gentile, D.R.,Bateman, L.A.,Zaidman, D.,Balius, T.E.,Nomura, D.K.,Burke, J.E.,Shokat, K.M.,London, N. (deposition date: 2017-08-22, release date: 2018-01-31, Last modification date: 2023-10-04)
Primary citation	Nnadi, C.I.,Jenkins, M.L.,Gentile, D.R.,Bateman, L.A.,Zaidman, D.,Balius, T.E.,Nomura, D.K.,Burke, J.E.,Shokat, K.M.,London, N. Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model, 58:464-471, 2018 Cited by PubMed: 29320178 DOI: 10.1021/acs.jcim.7b00399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation