6ARK
Crystal Structure of compound 10 covalently bound to K-Ras G12C
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH305 |
| A | HOH308 |
| A | VAL14 |
| A | HOH327 |
| A | HOH343 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | ASP57 |
| A | GDP201 |
| A | HOH305 |
| A | HOH308 |
| A | HOH310 |
| A | HOH314 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue BQD A 203 |
| Chain | Residue |
| A | CYS12 |
| A | ASN86 |
| A | ASP92 |
| A | HIS95 |
| A | GLN99 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | ASN85 |
| A | GLU91 |
| A | HIS94 |
| A | LEU120 |
| A | PRO121 |
| A | SER122 |
| A | HOH311 |
| A | HOH313 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 205 |
| Chain | Residue |
| A | ASP47 |
| A | GLN150 |
| A | GLY151 |
| A | ASP154 |
| A | TYR157 |
| A | HOH306 |
| A | HOH319 |
| A | HOH325 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
