8AJ8

Structure of p110 gamma bound to the p84 regulatory subunit

Summary for 8AJ8

Entry DOI	10.2210/pdb8aj8/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 6 (2 entities in total)
Functional Keywords	pi3k, pik3cg, pik3r6, phosphoinositide 3-kinase, p110, p84, signaling protein
Biological source	Sus scrofa (pig) More
Total number of polymer chains	8
Total formula weight	846402.87
Authors	Burke, J.E.,Williams, R.L.,Zhang, X. (deposition date: 2022-07-27, release date: 2023-03-22, Last modification date: 2024-02-07)
Primary citation	Rathinaswamy, M.K.,Jenkins, M.L.,Duewell, B.R.,Zhang, X.,Harris, N.J.,Evans, J.T.,Stariha, J.T.B.,Dalwadi, U.,Fleming, K.D.,Ranga-Prasad, H.,Yip, C.K.,Williams, R.L.,Hansen, S.D.,Burke, J.E. Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs. Cell Rep, 42:112172-112172, 2023 Cited by PubMed: 36842083 DOI: 10.1016/j.celrep.2023.112172 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (8.5 Å)

Structure validation