8AJ8

Structure of p110 gamma bound to the p84 regulatory subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001525	biological_process	angiogenesis
A	0002376	biological_process	immune system process
A	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
A	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
A	0006629	biological_process	lipid metabolic process
A	0006897	biological_process	endocytosis
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0016477	biological_process	cell migration
A	0016740	molecular_function	transferase activity
A	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A	0048015	biological_process	phosphatidylinositol-mediated signaling
A	0106310	molecular_function	protein serine kinase activity
B	0001525	biological_process	angiogenesis
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005942	cellular_component	phosphatidylinositol 3-kinase complex
B	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0045582	biological_process	positive regulation of T cell differentiation
B	0045766	biological_process	positive regulation of angiogenesis
B	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
B	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
C	0000166	molecular_function	nucleotide binding
C	0001525	biological_process	angiogenesis
C	0002376	biological_process	immune system process
C	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
C	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
C	0006629	biological_process	lipid metabolic process
C	0006897	biological_process	endocytosis
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
C	0016477	biological_process	cell migration
C	0016740	molecular_function	transferase activity
C	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
C	0035022	biological_process	positive regulation of Rac protein signal transduction
C	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
C	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
C	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
C	0048015	biological_process	phosphatidylinositol-mediated signaling
C	0106310	molecular_function	protein serine kinase activity
D	0001525	biological_process	angiogenesis
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0005942	cellular_component	phosphatidylinositol 3-kinase complex
D	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0016020	cellular_component	membrane
D	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
D	0043406	biological_process	positive regulation of MAP kinase activity
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045766	biological_process	positive regulation of angiogenesis
D	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
D	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
E	0000166	molecular_function	nucleotide binding
E	0001525	biological_process	angiogenesis
E	0002376	biological_process	immune system process
E	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
E	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
E	0006629	biological_process	lipid metabolic process
E	0006897	biological_process	endocytosis
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
E	0016477	biological_process	cell migration
E	0016740	molecular_function	transferase activity
E	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
E	0035022	biological_process	positive regulation of Rac protein signal transduction
E	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
E	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
E	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
E	0048015	biological_process	phosphatidylinositol-mediated signaling
E	0106310	molecular_function	protein serine kinase activity
F	0001525	biological_process	angiogenesis
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0005942	cellular_component	phosphatidylinositol 3-kinase complex
F	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0016020	cellular_component	membrane
F	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
F	0043406	biological_process	positive regulation of MAP kinase activity
F	0045582	biological_process	positive regulation of T cell differentiation
F	0045766	biological_process	positive regulation of angiogenesis
F	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
F	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
G	0000166	molecular_function	nucleotide binding
G	0001525	biological_process	angiogenesis
G	0002376	biological_process	immune system process
G	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
G	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
G	0006629	biological_process	lipid metabolic process
G	0006897	biological_process	endocytosis
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
G	0010595	biological_process	positive regulation of endothelial cell migration
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
G	0016477	biological_process	cell migration
G	0016740	molecular_function	transferase activity
G	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
G	0035022	biological_process	positive regulation of Rac protein signal transduction
G	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
G	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
G	0048015	biological_process	phosphatidylinositol-mediated signaling
G	0106310	molecular_function	protein serine kinase activity
H	0001525	biological_process	angiogenesis
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0005942	cellular_component	phosphatidylinositol 3-kinase complex
H	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0016020	cellular_component	membrane
H	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
H	0043406	biological_process	positive regulation of MAP kinase activity
H	0045582	biological_process	positive regulation of T cell differentiation
H	0045766	biological_process	positive regulation of angiogenesis
H	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
H	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ

Chain	Residue	Details
A	PHE832-GLN846

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN

Chain	Residue	Details
A	SER931-ASN951

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	68
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090628","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"UniProtKB","id":"Q9JHG7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---