Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8AJ8

Structure of p110 gamma bound to the p84 regulatory subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
A	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0010595	biological_process	positive regulation of endothelial cell migration
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0016477	biological_process	cell migration
A	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A	0048015	biological_process	phosphatidylinositol-mediated signaling
A	0106310	molecular_function	protein serine kinase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005942	cellular_component	phosphatidylinositol 3-kinase complex
B	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
B	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0045582	biological_process	positive regulation of T cell differentiation
B	0045766	biological_process	positive regulation of angiogenesis
B	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
B	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
C	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
C	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0016301	molecular_function	kinase activity
C	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
C	0016477	biological_process	cell migration
C	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
C	0035022	biological_process	positive regulation of Rac protein signal transduction
C	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
C	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
C	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
C	0048015	biological_process	phosphatidylinositol-mediated signaling
C	0106310	molecular_function	protein serine kinase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0005942	cellular_component	phosphatidylinositol 3-kinase complex
D	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
D	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0016020	cellular_component	membrane
D	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
D	0043406	biological_process	positive regulation of MAP kinase activity
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045766	biological_process	positive regulation of angiogenesis
D	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
D	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
E	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
E	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
E	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
E	0010595	biological_process	positive regulation of endothelial cell migration
E	0016301	molecular_function	kinase activity
E	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
E	0016477	biological_process	cell migration
E	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
E	0035022	biological_process	positive regulation of Rac protein signal transduction
E	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
E	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
E	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
E	0048015	biological_process	phosphatidylinositol-mediated signaling
E	0106310	molecular_function	protein serine kinase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0005942	cellular_component	phosphatidylinositol 3-kinase complex
F	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
F	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0016020	cellular_component	membrane
F	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
F	0043406	biological_process	positive regulation of MAP kinase activity
F	0045582	biological_process	positive regulation of T cell differentiation
F	0045766	biological_process	positive regulation of angiogenesis
F	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
F	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
G	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
G	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
G	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
G	0010595	biological_process	positive regulation of endothelial cell migration
G	0016301	molecular_function	kinase activity
G	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
G	0016477	biological_process	cell migration
G	0035005	molecular_function	1-phosphatidylinositol-4-phosphate 3-kinase activity
G	0035022	biological_process	positive regulation of Rac protein signal transduction
G	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
G	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
G	0048015	biological_process	phosphatidylinositol-mediated signaling
G	0106310	molecular_function	protein serine kinase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0005942	cellular_component	phosphatidylinositol 3-kinase complex
H	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
H	0005944	cellular_component	phosphatidylinositol 3-kinase complex, class IB
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0016020	cellular_component	membrane
H	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
H	0043406	biological_process	positive regulation of MAP kinase activity
H	0045582	biological_process	positive regulation of T cell differentiation
H	0045766	biological_process	positive regulation of angiogenesis
H	0046934	molecular_function	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
H	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ

Chain	Residue	Details
A	PHE832-GLN846

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN

Chain	Residue	Details
A	SER931-ASN951

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	68
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090628","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"UniProtKB","id":"Q9JHG7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)