Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11

Summary for 5EUQ

DescriptorRas-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordslipid kinase, gtpase complex, transferase-signaling protein complex, transferase/signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight86500.59
Burke, J.E.,Fowler, M.L. (deposition date: 2015-11-19, release date: 2016-02-24, Last modification date: 2020-01-08)
Primary citation
Rutaganira, F.U.,Fowler, M.L.,McPhail, J.A.,Gelman, M.A.,Nguyen, K.,Xiong, A.,Dornan, G.L.,Tavshanjian, B.,Glenn, J.S.,Shokat, K.M.,Burke, J.E.
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.
J.Med.Chem., 59:1830-1839, 2016
PubMed: 26885694 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.5b01311
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25822 0.2%0 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-14