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5EUQ

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11

Summary for 5EUQ
Entry DOI10.2210/pdb5euq/pdb
DescriptorRas-related protein Rab-11A, Phosphatidylinositol 4-kinase beta, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordslipid kinase, gtpase complex, transferase-signaling protein complex, transferase/signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight86500.59
Authors
Burke, J.E.,Fowler, M.L. (deposition date: 2015-11-19, release date: 2016-02-24, Last modification date: 2023-09-27)
Primary citationRutaganira, F.U.,Fowler, M.L.,McPhail, J.A.,Gelman, M.A.,Nguyen, K.,Xiong, A.,Dornan, G.L.,Tavshanjian, B.,Glenn, J.S.,Shokat, K.M.,Burke, J.E.
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta.
J.Med.Chem., 59:1830-1839, 2016
Cited by
PubMed: 26885694
DOI: 10.1021/acs.jmedchem.5b01311
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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