5EUQ
Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Ras-related protein Rab-11A | polymer | 219 | 24691.8 | 1 | UniProt (P62491) Pfam (PF00071) In PDB | Homo sapiens (Human) | Rab-11,YL8 |
2 | E | Phosphatidylinositol 4-kinase beta | polymer | 529 | 60683.8 | 1 | UniProt (Q9UBF8) UniProt (O02810) Pfam (PF21245) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns 4-kinase beta,NPIK,PI4K92 |
3 | B | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
4 | E | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | E | ~{N}-[5-[3-[[(4-hydroxyphenyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-4-methoxy-phenyl]-4-methyl-1,3-thiazol-2-yl]cyclopentanecarboxamide | non-polymer | 489.6 | 1 | Chemie (5S8) |
Sequence modifications
B: 1 - 216 (UniProt: P62491)
E: 121 - 287 (UniProt: Q9UBF8)
E: 288 - 507 (UniProt: O02810)
E: 508 - 784 (UniProt: Q9UBF8)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Leu 70 | Gln 70 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 117 | - | expression tag |
Ser 118 | - | expression tag |
His 119 | - | expression tag |
Met 120 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 294 | Ser 294 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85375.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1124.9 | |
All* | Total formula weight | 86500.6 |