Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5EUQ

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000922	cellular_component	spindle pole
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005771	cellular_component	multivesicular body
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005813	cellular_component	centrosome
B	0005814	cellular_component	centriole
B	0005828	cellular_component	kinetochore microtubule
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006887	biological_process	exocytosis
B	0007080	biological_process	mitotic metaphase chromosome alignment
B	0008017	molecular_function	microtubule binding
B	0010008	cellular_component	endosome membrane
B	0010634	biological_process	positive regulation of epithelial cell migration
B	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0019905	molecular_function	syntaxin binding
B	0030133	cellular_component	transport vesicle
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0030666	cellular_component	endocytic vesicle membrane
B	0030672	cellular_component	synaptic vesicle membrane
B	0030953	biological_process	astral microtubule organization
B	0031175	biological_process	neuron projection development
B	0031410	cellular_component	cytoplasmic vesicle
B	0031489	molecular_function	myosin V binding
B	0031982	cellular_component	vesicle
B	0032154	cellular_component	cleavage furrow
B	0032402	biological_process	melanosome transport
B	0032465	biological_process	regulation of cytokinesis
B	0032588	cellular_component	trans-Golgi network membrane
B	0032991	cellular_component	protein-containing complex
B	0034394	biological_process	protein localization to cell surface
B	0036258	biological_process	multivesicular body assembly
B	0043001	biological_process	Golgi to plasma membrane protein transport
B	0045335	cellular_component	phagocytic vesicle
B	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
B	0048227	biological_process	plasma membrane to endosome transport
B	0051223	biological_process	regulation of protein transport
B	0051650	biological_process	establishment of vesicle localization
B	0051959	molecular_function	dynein light intermediate chain binding
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0060627	biological_process	regulation of vesicle-mediated transport
B	0061502	biological_process	early endosome to recycling endosome transport
B	0061512	biological_process	protein localization to cilium
B	0070062	cellular_component	extracellular exosome
B	0071806	biological_process	protein transmembrane transport
B	0072594	biological_process	establishment of protein localization to organelle
B	0072659	biological_process	protein localization to plasma membrane
B	0090150	biological_process	establishment of protein localization to membrane
B	0090307	biological_process	mitotic spindle assembly
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098830	cellular_component	presynaptic endosome
B	0098837	cellular_component	postsynaptic recycling endosome
B	0098876	biological_process	vesicle-mediated transport to the plasma membrane
B	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
B	0098978	cellular_component	glutamatergic synapse
B	0099003	biological_process	vesicle-mediated transport in synapse
B	0099532	biological_process	synaptic vesicle endosomal processing
B	0150093	biological_process	amyloid-beta clearance by transcytosis
B	1902017	biological_process	regulation of cilium assembly
B	1902954	biological_process	regulation of early endosome to recycling endosome transport
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1903438	biological_process	positive regulation of mitotic cytokinetic process
B	1904779	biological_process	regulation of protein localization to centrosome
B	1990182	biological_process	exosomal secretion
B	2001135	biological_process	regulation of endocytic recycling
E	0016301	molecular_function	kinase activity
E	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue GDP B 301

Chain	Residue
B	SER20
B	LEU38
B	ASN124
B	LYS125
B	ASP127
B	LEU128
B	SER154
B	ALA155
B	LEU156
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	ASN26
B	PHE36
B	ASN37

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 E 1001

Chain	Residue
E	HIS605
E	LYS608
E	ASN659

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 E 1002

Chain	Residue
E	TYR183
E	LYS195
E	ARG232
E	GLY233
E	LYS235
E	LEU236

site_id	AC4
Number of Residues	13
Details	binding site for residue 5S8 E 1003

Chain	Residue
E	LEU374
E	PRO381
E	ILE547
E	LYS549
E	TYR583
E	ILE595
E	PRO597
E	VAL598
E	ALA601
E	GLY660
E	ASN661
E	LEU663
E	ILE673

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
B	VAL14-LEU27

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKcg.DDLRQEllafQ

Chain	Residue	Details
E	VAL548-GLN562

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycLvcYLLqVkDRHngN

Chain	Residue	Details
E	SER641-ASN661

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15837192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)