8DP0

Structure of p110 gamma bound to the Ras inhibitory nanobody NB7

Summary for 8DP0

Entry DOI	10.2210/pdb8dp0/pdb
EMDB information	27627
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Nanobody NB7 (2 entities in total)
Functional Keywords	pi3k, p110, pik3cg, phosphoinositide 3-kinase, pip3, transferase-immune system complex, transferase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	141202.40
Authors	Burke, J.E.,Nam, S.E.,Rathinaswamy, M.K.,Yip, C.K. (deposition date: 2022-07-14, release date: 2023-07-19)
Primary citation	Harris, N.J.,Jenkins, M.L.,Nam, S.E.,Rathinaswamy, M.K.,Parson, M.A.H.,Ranga-Prasad, H.,Dalwadi, U.,Moeller, B.E.,Sheeky, E.,Hansen, S.D.,Yip, C.K.,Burke, J.E. Allosteric activation or inhibition of PI3K gamma mediated through conformational changes in the p110 gamma helical domain. Elife, 12:-, 2023 Cited by PubMed: 37417733 DOI: 10.7554/eLife.88058 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.96 Å)

Structure validation