1DBX
| Crystal structure of cysteinyl-tRNA(Pro) deacylase from H. influenzae (HI1434) | Descriptor: | cysteinyl-tRNA(Pro) deacylase | Authors: | Zhang, H, Huang, K, Li, Z, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 1999-11-03 | Release date: | 2000-06-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications. Proteins, 40, 2000
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1XF7
| High Resolution NMR Structure of the Wilms' Tumor Suppressor Protein (WT1) Finger 3 | Descriptor: | Wilms' Tumor Protein, ZINC ION | Authors: | Lachenmann, M.J, Ladbury, J.E, Dong, J, Huang, K, Carey, P, Weiss, M.A. | Deposit date: | 2004-09-14 | Release date: | 2004-12-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity Biochemistry, 43, 2004
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1XRZ
| NMR Structure of a Zinc Finger with Cyclohexanylalanine Substituted for the Central Aromatic Residue | Descriptor: | ZINC ION, Zinc finger Y-chromosomal protein | Authors: | Lachenmann, M.J, Ladbury, J.E, Qian, X, Huang, K, Singh, R, Weiss, M.A. | Deposit date: | 2004-10-17 | Release date: | 2004-11-30 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Solvation and the hidden thermodynamics of a zinc finger probed
by nonstandard repair of a protein crevice Protein Sci., 13, 2004
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1XW7
| Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Wan, Z.L, Huang, K, Xu, B, Chu, Y.C, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2004-10-29 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama Biochemistry, 44, 2005
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1S5R
| Solution Structure of HBP1 SID-mSin3A PAH2 Complex | Descriptor: | Sin3a protein, high mobility group box transcription factor 1 | Authors: | Swanson, K.A, Knoepfler, P.S, Huang, K, Kang, R.S, Cowley, S.M, Laherty, C.D, Eisenman, R.N, Radhakrishnan, I. | Deposit date: | 2004-01-21 | Release date: | 2004-07-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat.Struct.Mol.Biol., 11, 2004
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3JCX
| Canine Parvovirus complexed with Fab E | Descriptor: | Capsid protein 2, Fab E heavy chain, Fab E light chain | Authors: | Organtini, L.J, Iketani, S, Huang, K, Ashley, R.E, Makhov, A.M, Conway, J.F, Parrish, C.R, Hafenstein, S. | Deposit date: | 2016-03-21 | Release date: | 2016-07-20 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus. J.Virol., 90, 2016
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3JSD
| Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | Deposit date: | 2009-09-10 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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3V1G
| Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | Deposit date: | 2011-12-09 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health To be Published
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3V19
| Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | Deposit date: | 2011-12-09 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health To be Published
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6BP2
| Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | Deposit date: | 2017-11-21 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
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6ISN
| Phosphoglycerate mutase 1 complexed with a small molecule inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-chloro-N-(3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)benzene-1-sulfonamide, CHLORIDE ION, ... | Authors: | Jiang, L.L, Zhou, L, Huang, K. | Deposit date: | 2018-11-17 | Release date: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Phosphoglycerate mutase 1 complexed with a small molecule inhibitor To Be Published
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2L1Z
| NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. | Deposit date: | 2010-08-09 | Release date: | 2011-08-31 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Chiral Protein Engineering and its Application in G Health To be Published
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2L1Y
| NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. | Deposit date: | 2010-08-09 | Release date: | 2011-08-31 | Method: | SOLUTION NMR | Cite: | Chiral Protein Engineering and its Application in G Health To be Published
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2JZQ
| Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures | Descriptor: | Insulin | Authors: | Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A. | Deposit date: | 2008-01-11 | Release date: | 2008-02-26 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J.Biol.Chem., 283, 2008
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2KQQ
| NMR structure of human insulin mutant gly-b8-d-ala, his-b10-asp, pro-b28-lys, lys-b29-pro, 20 structures | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Hua, Q.X, Wan, Z.L, Zhao, M, Jia, W, Huang, K, Weiss, M.A. | Deposit date: | 2009-11-13 | Release date: | 2010-11-24 | Last modified: | 2021-10-13 | Method: | SOLUTION NMR | Cite: | Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog. To be Published
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2NU0
| Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I, and Tyr18I | Descriptor: | Ovomucoid, Streptogrisin B, Protease B | Authors: | Bateman, K.S, Anderson, S, Lu, W, Qasim, M.A, Huang, K, Laskowski Jr, M, James, M.N.G. | Deposit date: | 2006-11-08 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I, and Tyr18I To be Published
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2K9R
| Enhancing the activity of insulin by stereospecific unfolding | Descriptor: | Insulin | Authors: | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2008-10-23 | Release date: | 2008-11-11 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
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2K91
| Enhancing the activity of insulin by stereospecific unfolding | Descriptor: | Insulin | Authors: | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2008-09-29 | Release date: | 2008-11-18 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
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2NU1
| Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I and Tyr18I | Descriptor: | Ovomucoid, Streptogrisin B | Authors: | Bateman, K.S, Anderson, S, Lu, W, Qasim, M.A, Huang, K, Laskowski Jr, M, James, M.N.G. | Deposit date: | 2006-11-08 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular structures of the complexes of SGPB with OMTKY3 aromatic P1 variants Trp18I, His18I, Phe18I and Tyr18I To be Published
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2KJU
| NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures | Descriptor: | Insulin | Authors: | Hua, Q.X, Huang, K, Hu, S.Q, Katsoyanni, P, Weiss, M.A. | Deposit date: | 2009-06-10 | Release date: | 2010-06-16 | Last modified: | 2021-10-13 | Method: | SOLUTION NMR | Cite: | Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn To be Published
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2NU3
| Accommodation of positively-charged residues in a hydrophobic specificity pocket: Crystal structures of SGPB in complex with OMTKY3 variants Lys18I and Arg18I | Descriptor: | Ovomucoid, Streptogrisin B, Proteinase B | Authors: | Bateman, K.S, Anderson, S, Lu, W, Qasim, M.A, Huang, K, Laskowski Jr, M, James, M.N.G. | Deposit date: | 2006-11-08 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Accommodation of positively-charged residues in a hydrophobic specificity pocket: Crystal structures of SGPB in complex with OMTKY3 variants Lys18I and Arg18I To be Published
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3R8F
| Replication initiator DnaA bound to AMPPCP and single-stranded DNA | Descriptor: | 5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', Chromosomal replication initiator protein dnaA, MAGNESIUM ION, ... | Authors: | Duderstadt, K.E, Chuang, K, Berger, J.M. | Deposit date: | 2011-03-23 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.366 Å) | Cite: | DNA stretching by bacterial initiators promotes replication origin opening. Nature, 478, 2011
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8HZJ
| A new fluorescent RNA aptamer bound with N571 | Descriptor: | (5~{Z})-5-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]methylidene]-3-methyl-2-[(~{E})-2-phenylethenyl]imidazol-4-one, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Huang, K.Y, Ren, A.M. | Deposit date: | 2023-01-09 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat.Chem.Biol., 2024
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8HZE
| A new fluorescent RNA aptamer bound with N | Descriptor: | (5~{Z})-5-[[4-[2-hydroxyethyl(methyl)amino]phenyl]methylidene]-3-methyl-2-[(~{E})-2-phenylethenyl]imidazol-4-one, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Huang, K.Y, Ren, A.M. | Deposit date: | 2023-01-09 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat.Chem.Biol., 2024
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8HZM
| A new fluorescent RNA aptamer bound with N, manganese soak | Descriptor: | (5~{Z})-5-[[4-[2-hydroxyethyl(methyl)amino]phenyl]methylidene]-3-methyl-2-[(~{E})-2-phenylethenyl]imidazol-4-one, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Huang, K.Y, Ren, A.M. | Deposit date: | 2023-01-09 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat.Chem.Biol., 2024
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