5JNY
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![BU of 5jny by Molmil](/molmil-images/mine/5jny) | Crystal Structure of 10E8 Fab | Descriptor: | 10E8 Heavy Chain, 10E8 Light Chain, CHLORIDE ION, ... | Authors: | Ofek, G, Kwong, P. | Deposit date: | 2016-05-01 | Release date: | 2016-07-13 | Method: | X-RAY DIFFRACTION (3.041 Å) | Cite: | Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8. Plos One, 11, 2016
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6UDA
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![BU of 6uda by Molmil](/molmil-images/mine/6uda) | Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CH235 UCA heavy chain Fab, CH235 UCA light chain Fab, ... | Authors: | Henderson, R, Acharya, P. | Deposit date: | 2019-09-19 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancester of CH235 lineage CD4bs broadly neutralizing antibodies. Plos Pathog., 15, 2019
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8TNG
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![BU of 8tng by Molmil](/molmil-images/mine/8tng) | |
8TNH
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![BU of 8tnh by Molmil](/molmil-images/mine/8tnh) | |
8TNI
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![BU of 8tni by Molmil](/molmil-images/mine/8tni) | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ... | Authors: | Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J. | Deposit date: | 2023-08-01 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex To Be Published
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4GW4
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![BU of 4gw4 by Molmil](/molmil-images/mine/4gw4) | Crystal structure of 3BNC60 Fab with P61A mutation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC60 Fab Heavy-chain, 3BNC60 Fab Light-chain | Authors: | Diskin, R, Fu, B.Z, Bjorkman, P.J. | Deposit date: | 2012-08-31 | Release date: | 2013-04-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell(Cambridge,Mass.), 153, 2013
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4Q6I
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![BU of 4q6i by Molmil](/molmil-images/mine/4q6i) | Crystal structure of murine 2D5 Fab, a potent anti-CD4 HIV-1-neutralizing antibody in complex with CD4 | Descriptor: | Heavy chain of murine 2D5 Fab, Light chain of murine 2D5 Fab, T-cell surface glycoprotein CD4 | Authors: | Boyington, J.C, Nabel, G.J, Mascola, J.R. | Deposit date: | 2014-04-22 | Release date: | 2014-07-23 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med, 6, 2014
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4RFE
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![BU of 4rfe by Molmil](/molmil-images/mine/4rfe) | Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab | Descriptor: | CHLORIDE ION, Fab heavy chain of ADCC-potent anti-HIV-1 antibody JR4, Fab light chain of ADCC-potent anti-HIV-1 antibody JR4, ... | Authors: | Wu, X, Gohain, N, Tolbert, W.D, Pazgier, M. | Deposit date: | 2014-09-25 | Release date: | 2015-07-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89, 2015
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4RFO
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![BU of 4rfo by Molmil](/molmil-images/mine/4rfo) | Crystal structure of the ADCC-Potent Antibody N60-I3 Fab in complex with HIV-1 Clade A/E gp120 and M48u1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 clade A/E gp120, N60-i3 Fab heavy chain, ... | Authors: | Tolbert, W.D, Gohain, N, Pazgier, M. | Deposit date: | 2014-09-26 | Release date: | 2015-07-15 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89, 2015
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4RFN
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![BU of 4rfn by Molmil](/molmil-images/mine/4rfn) | Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, ... | Authors: | Gohain, N, Tolbert, W.D, Pazgier, M. | Deposit date: | 2014-09-26 | Release date: | 2015-07-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89, 2015
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6XEY
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![BU of 6xey by Molmil](/molmil-images/mine/6xey) | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-4 | Descriptor: | 2-4 Heavy Chain, 2-4 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rapp, M, Shapiro, L, Ho, D.D. | Deposit date: | 2020-06-14 | Release date: | 2020-07-22 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature, 584, 2020
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7RIB
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![BU of 7rib by Molmil](/molmil-images/mine/7rib) | Griffithsin mutant Y28F/Y68F/Y110F | Descriptor: | Griffithsin, SULFATE ION, alpha-D-mannopyranose | Authors: | Zhao, G, Sun, J, Bewley, C.A. | Deposit date: | 2021-07-19 | Release date: | 2022-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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7RKI
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![BU of 7rki by Molmil](/molmil-images/mine/7rki) | Griffithsin-S10Y/S42Y/S88Y | Descriptor: | Griffithsin, alpha-D-mannopyranose | Authors: | Sun, J.D, Zhao, G.X. | Deposit date: | 2021-07-22 | Release date: | 2022-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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7RIA
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![BU of 7ria by Molmil](/molmil-images/mine/7ria) | Griffithsin variant Y28A/Y68A/Y110A | Descriptor: | Griffithsin, SULFATE ION, alpha-D-mannopyranose | Authors: | Zhao, G, Sun, J, Bewley, C.A. | Deposit date: | 2021-07-19 | Release date: | 2022-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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7RIC
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![BU of 7ric by Molmil](/molmil-images/mine/7ric) | Griffithsin variant Y28W/Y68W/Y110W | Descriptor: | Griffithsin | Authors: | Zhao, G, Sun, J, Bewley, C.A. | Deposit date: | 2021-07-19 | Release date: | 2022-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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7RID
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![BU of 7rid by Molmil](/molmil-images/mine/7rid) | Griffithsin variant Y28A | Descriptor: | Griffithsin | Authors: | Zhao, G, Sun, J, Bewley, C.A. | Deposit date: | 2021-07-19 | Release date: | 2022-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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7RKG
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![BU of 7rkg by Molmil](/molmil-images/mine/7rkg) | Griffithsin mutant Y28W | Descriptor: | Griffithsin, alpha-D-mannopyranose | Authors: | Zhao, G, Sun, J, Bewley, C. | Deposit date: | 2021-07-22 | Release date: | 2022-05-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | C 3 -Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity. Acs Chem.Biol., 17, 2022
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4NGH
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![BU of 4ngh by Molmil](/molmil-images/mine/4ngh) | |
4NHC
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![BU of 4nhc by Molmil](/molmil-images/mine/4nhc) | |
7TTM
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![BU of 7ttm by Molmil](/molmil-images/mine/7ttm) | |
7TTX
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![BU of 7ttx by Molmil](/molmil-images/mine/7ttx) | |
5KO2
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![BU of 5ko2 by Molmil](/molmil-images/mine/5ko2) | Mouse pgp 34 linker deleted mutant Hg derivative | Descriptor: | MERCURY (II) ION, Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-06-29 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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5KOY
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![BU of 5koy by Molmil](/molmil-images/mine/5koy) | Mouse pgp 34 linker deleted bound with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-07-01 | Release date: | 2016-12-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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7TTY
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![BU of 7tty by Molmil](/molmil-images/mine/7tty) | |
5KPD
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![BU of 5kpd by Molmil](/molmil-images/mine/5kpd) | Mouse pgp 34 linker deleted double EQ mutant | Descriptor: | Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-07-03 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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