5KO2

Mouse pgp 34 linker deleted mutant Hg derivative

Summary for 5KO2

Entry DOI	10.2210/pdb5ko2/pdb
Related	5KOY 5KPD 5KPI 5KPJ
Descriptor	Multidrug resistance protein 1A, MERCURY (II) ION (2 entities in total)
Functional Keywords	mouse pgp, multidrug resistance, drug transport, mercury derivative, hydrolase
Biological source	Mus musculus (Mouse)
Cellular location	Cell membrane; Multi-pass membrane protein: P21447
Total number of polymer chains	2
Total formula weight	278394.92
Authors	Xia, D.,Esser, L.,Zhou, F. (deposition date: 2016-06-29, release date: 2016-11-30, Last modification date: 2023-09-27)
Primary citation	Esser, L.,Zhou, F.,Pluchino, K.M.,Shiloach, J.,Ma, J.,Tang, W.K.,Gutierrez, C.,Zhang, A.,Shukla, S.,Madigan, J.P.,Zhou, T.,Kwong, P.D.,Ambudkar, S.V.,Gottesman, M.M.,Xia, D. Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292:446-461, 2017 Cited by PubMed: 27864369 DOI: 10.1074/jbc.M116.755884 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation