4NHC
Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41.
Summary for 4NHC
| Entry DOI | 10.2210/pdb4nhc/pdb |
| Related | 4NGH |
| Related PRD ID | PRD_001209 |
| Descriptor | FAB LIGHT CHAIN, FAB HEAVY CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41), ... (6 entities in total) |
| Functional Keywords | immunoglobulin fold, beta-sandwich, 4e10 fab, antibody-epitope complex, gp41 hiv-1, hydrocarbon staple, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 3 |
| Total formula weight | 49798.46 |
| Authors | Irimia, A.,Wilson, I.A. (deposition date: 2013-11-04, release date: 2014-12-03, Last modification date: 2023-12-06) |
| Primary citation | Bird, G.H.,Irimia, A.,Ofek, G.,Kwong, P.D.,Wilson, I.A.,Walensky, L.D. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat.Struct.Mol.Biol., 21:1058-1067, 2014 Cited by PubMed: 25420104DOI: 10.1038/nsmb.2922 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.912 Å) |
Structure validation
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