4NHC
Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DIV P 678 |
| Chain | Residue |
| P | ASN674 |
| P | ILE675 |
| P | THR676 |
| P | ASN677 |
| P | LEU679 |
| P | MK8681 |
| P | ILE682 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TFA L 301 |
| Chain | Residue |
| L | VAL115 |
| L | PHE116 |
| L | LYS207 |
| L | HOH412 |
| H | THR133 |
| H | SER134 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 H 301 |
| Chain | Residue |
| H | SER28 |
| H | PHE29 |
| H | SER30 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TFA H 302 |
| Chain | Residue |
| H | GLN39 |
| H | ALA40 |
| H | PRO41 |
| H | GLY42 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR206-HIS212 | |
| L | TYR192-HIS198 |
