4NGH

Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41 and a tethered phosphate moiety.

Summary for 4NGH

• Entry DOI: 10.2210/pdb4ngh/pdb
• Related: 4NHC
• Related PRD ID: PRD_001208
• Descriptor: FAB LIGHT CHAIN, FAB HEAVY CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41), ... (4 entities in total)
• Functional Keywords: immunoglobulin fold, beta-sandwich, 4e10 fab, antibody-epitope complex, gp41 hiv-1, hydrocarbon staple, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 49670.49

Authors

Irimia, A.,Wilson, I.A. (deposition date: 2013-11-01, release date: 2014-12-03, Last modification date: 2023-12-06)

• Primary citation: Bird, G.H.,Irimia, A.,Ofek, G.,Kwong, P.D.,Wilson, I.A.,Walensky, L.D.; Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.; Nat.Struct.Mol.Biol., 21:1058-1067, 2014; PubMed: 25420104; DOI: 10.1038/nsmb.2922

Experimental method

X-RAY DIFFRACTION (2.68 Å)