8TNI

Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex

Summary for 8TNI

• Entry DOI: 10.2210/pdb8tni/pdb
• EMDB information: 41415 41416 41417
• Descriptor: HIV-1 BG505 DS-SOSIP gp120, HIV-1 BG505 DS-SOSIP gp41, Light chain of bi-specific antibody CAP256L-R27, ... (8 entities in total)
• Functional Keywords: hiv-1 envelope, bi-specific, antibody, nanobody, vhh, llama, bg505 ds-sosip, neutralization, cap256, r27, immunization, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 10
• Total formula weight: 366676.98

Authors

Zhou, T.,Morano, N.C.,Roark, R.S.,Kwong, P.D.,Xu, J. (deposition date: 2023-08-01, release date: 2024-05-08)

• Primary citation: Xu, J.,Zhou, T.; Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.61 Å)