5KOY

Mouse pgp 34 linker deleted bound with ATP

Summary for 5KOY

Entry DOI	10.2210/pdb5koy/pdb
Related	5KO2 5KPD 5KPI 5KPJ
Descriptor	Multidrug resistance protein 1A, ADENOSINE-5'-TRIPHOSPHATE (2 entities in total)
Functional Keywords	mouse pgp, multidrug resistance, drug transport, atp bound, hydrolase
Biological source	Mus musculus (Mouse)
Cellular location	Cell membrane; Multi-pass membrane protein: P21447
Total number of polymer chains	2
Total formula weight	276601.02
Authors	Xia, D.,Esser, L.,Zhou, F. (deposition date: 2016-07-01, release date: 2016-12-14, Last modification date: 2023-10-04)
Primary citation	Esser, L.,Zhou, F.,Pluchino, K.M.,Shiloach, J.,Ma, J.,Tang, W.K.,Gutierrez, C.,Zhang, A.,Shukla, S.,Madigan, J.P.,Zhou, T.,Kwong, P.D.,Ambudkar, S.V.,Gottesman, M.M.,Xia, D. Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292:446-461, 2017 Cited by PubMed: 27864369 DOI: 10.1074/jbc.M116.755884 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.85 Å)

Structure validation