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5KOY

Mouse pgp 34 linker deleted bound with ATP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007565biological_processfemale pregnancy
A0007595biological_processlactation
A0007623biological_processcircadian rhythm
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009914biological_processhormone transport
A0010046biological_processresponse to mycotoxin
A0014070biological_processresponse to organic cyclic compound
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0031526cellular_componentbrush border membrane
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0033280biological_processresponse to vitamin D
A0033762biological_processresponse to glucagon
A0035633biological_processmaintenance of blood-brain barrier
A0036146biological_processcellular response to mycotoxin
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043215biological_processdaunorubicin transport
A0045177cellular_componentapical part of cell
A0045332biological_processphospholipid translocation
A0046581cellular_componentintercellular canaliculus
A0046686biological_processresponse to cadmium ion
A0046865biological_processterpenoid transport
A0050892biological_processintestinal absorption
A0055085biological_processtransmembrane transport
A0060856biological_processestablishment of blood-brain barrier
A0071217biological_processcellular response to external biotic stimulus
A0071222biological_processcellular response to lipopolysaccharide
A0071236biological_processcellular response to antibiotic
A0071312biological_processcellular response to alkaloid
A0071356biological_processcellular response to tumor necrosis factor
A0071392biological_processcellular response to estradiol stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071548biological_processresponse to dexamethasone
A0071549biological_processcellular response to dexamethasone stimulus
A0090554molecular_functionphosphatidylcholine floppase activity
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0097068biological_processresponse to thyroxine
A0097305biological_processresponse to alcohol
A0097327biological_processresponse to antineoplastic agent
A0099038molecular_functionceramide floppase activity
A0099040biological_processceramide translocation
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902065biological_processresponse to L-glutamate
A1902396biological_processprotein localization to bicellular tight junction
A1903416biological_processresponse to glycoside
A1904057biological_processnegative regulation of sensory perception of pain
A1904148biological_processcellular response to nonylphenol
A1904446biological_processpositive regulation of establishment of Sertoli cell barrier
A1904478biological_processregulation of intestinal absorption
A1905231biological_processcellular response to borneol
A1905232biological_processcellular response to L-glutamate
A1905233biological_processresponse to codeine
A1905235biological_processresponse to quercetin
A1905237biological_processresponse to cyclosporin A
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
A1990962biological_processxenobiotic transport across blood-brain barrier
A1990963biological_processestablishment of blood-retinal barrier
A2001025biological_processpositive regulation of response to drug
B0001666biological_processresponse to hypoxia
B0001890biological_processplacenta development
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0007565biological_processfemale pregnancy
B0007595biological_processlactation
B0007623biological_processcircadian rhythm
B0008559molecular_functionABC-type xenobiotic transporter activity
B0009410biological_processresponse to xenobiotic stimulus
B0009914biological_processhormone transport
B0010046biological_processresponse to mycotoxin
B0014070biological_processresponse to organic cyclic compound
B0015562molecular_functionefflux transmembrane transporter activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016887molecular_functionATP hydrolysis activity
B0022857molecular_functiontransmembrane transporter activity
B0031526cellular_componentbrush border membrane
B0031667biological_processresponse to nutrient levels
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032570biological_processresponse to progesterone
B0033189biological_processresponse to vitamin A
B0033280biological_processresponse to vitamin D
B0033762biological_processresponse to glucagon
B0035633biological_processmaintenance of blood-brain barrier
B0036146biological_processcellular response to mycotoxin
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0043215biological_processdaunorubicin transport
B0045177cellular_componentapical part of cell
B0045332biological_processphospholipid translocation
B0046581cellular_componentintercellular canaliculus
B0046686biological_processresponse to cadmium ion
B0046865biological_processterpenoid transport
B0050892biological_processintestinal absorption
B0055085biological_processtransmembrane transport
B0060856biological_processestablishment of blood-brain barrier
B0071217biological_processcellular response to external biotic stimulus
B0071222biological_processcellular response to lipopolysaccharide
B0071236biological_processcellular response to antibiotic
B0071312biological_processcellular response to alkaloid
B0071356biological_processcellular response to tumor necrosis factor
B0071392biological_processcellular response to estradiol stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071548biological_processresponse to dexamethasone
B0071549biological_processcellular response to dexamethasone stimulus
B0090554molecular_functionphosphatidylcholine floppase activity
B0090555molecular_functionphosphatidylethanolamine flippase activity
B0097068biological_processresponse to thyroxine
B0097305biological_processresponse to alcohol
B0097327biological_processresponse to antineoplastic agent
B0099038molecular_functionceramide floppase activity
B0099040biological_processceramide translocation
B0140115biological_processexport across plasma membrane
B0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
B0140328molecular_functionfloppase activity
B0140359molecular_functionABC-type transporter activity
B1902065biological_processresponse to L-glutamate
B1902396biological_processprotein localization to bicellular tight junction
B1903416biological_processresponse to glycoside
B1904057biological_processnegative regulation of sensory perception of pain
B1904148biological_processcellular response to nonylphenol
B1904446biological_processpositive regulation of establishment of Sertoli cell barrier
B1904478biological_processregulation of intestinal absorption
B1905231biological_processcellular response to borneol
B1905232biological_processcellular response to L-glutamate
B1905233biological_processresponse to codeine
B1905235biological_processresponse to quercetin
B1905237biological_processresponse to cyclosporin A
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B1990962biological_processxenobiotic transport across blood-brain barrier
B1990963biological_processestablishment of blood-retinal barrier
B2001025biological_processpositive regulation of response to drug
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue ATP A 2000
ChainResidue
AASP160
ATYR397
AILE405
ASER425
AGLY428
ALYS429
ASER430
AGLN552

site_idAC2
Number of Residues12
Detailsbinding site for residue ATP B 2000
ChainResidue
BTYR397
BSER399
BSER425
BGLY426
BCYS427
BGLY428
BLYS429
BSER430
BTHR431
BGLN552
BARG901
BASP160

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
ChainResidueDetails
ALEU527-LEU541
ALEU1172-LEU1186

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1804
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-GLY43
BSER233-THR290
BGLU349-PRO741
BGLY808-PRO862
BSER905-LEU964
ALEU134-ILE182
ASER233-THR290
AGLU349-PRO741
AGLY808-PRO862
ASER905-LEU964
BMET1-GLY43
BLEU134-ILE182

site_idSWS_FT_FI2
Number of Residues494
DetailsTRANSMEM: Helical
ChainResidueDetails
ATRP44-LEU66
AGLU885-VAL904
AMET965-VAL987
AILE1004-ASN1025
BTRP44-LEU66
BTYR113-CYS133
BGLY183-PHE204
BLEU212-LEU232
BALA291-TYR312
BVAL327-ILE348
BGLU742-SER762
ATYR113-CYS133
BMET787-THR807
BILE863-LYS883
BGLU885-VAL904
BMET965-VAL987
BILE1004-ASN1025
AGLY183-PHE204
ALEU212-LEU232
AALA291-TYR312
AVAL327-ILE348
AGLU742-SER762
AMET787-THR807
AILE863-LYS883

site_idSWS_FT_FI3
Number of Residues206
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET67-TYR112
BPHE763-TYR786
BLYS884
BSER988-HIS1003
ATHR205-THR211
AGLY313-GLN326
APHE763-TYR786
ALYS884
ASER988-HIS1003
BMET67-TYR112
BTHR205-THR211
BGLY313-GLN326

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY423
ALEU1100
BGLY423
BLEU1100

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795
ChainResidueDetails
APRO690
BPRO690

site_idSWS_FT_FI6
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN83
AASN87
AASN90
BASN83
BASN87
BASN90

224004

PDB entries from 2024-08-21

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