4RFE
Crystal structure of ADCC-potent ANTI-HIV-1 Rhesus macaque antibody JR4 Fab
Summary for 4RFE
Entry DOI | 10.2210/pdb4rfe/pdb |
Related | 4H8W 4JZW 4RFN 4RFO |
Descriptor | Fab heavy chain of ADCC-potent anti-HIV-1 antibody JR4, Fab light chain of ADCC-potent anti-HIV-1 antibody JR4, SULFATE ION, ... (6 entities in total) |
Functional Keywords | hiv-1 gp120 specific antibody, cd4i antibody, adcc, hiv-1 env, anti-hiv-1 env antibody jr4, immune system |
Biological source | Macaca mulatta (rhesus macaque) More |
Total number of polymer chains | 8 |
Total formula weight | 190870.91 |
Authors | Wu, X.,Gohain, N.,Tolbert, W.D.,Pazgier, M. (deposition date: 2014-09-25, release date: 2015-07-15, Last modification date: 2023-09-20) |
Primary citation | Gohain, N.,Tolbert, W.D.,Acharya, P.,Yu, L.,Liu, T.,Zhao, P.,Orlandi, C.,Visciano, M.L.,Kamin-Lewis, R.,Sajadi, M.M.,Martin, L.,Robinson, J.E.,Kwong, P.D.,DeVico, A.L.,Ray, K.,Lewis, G.K.,Pazgier, M. Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89:8840-8854, 2015 Cited by PubMed: 26085162DOI: 10.1128/JVI.01232-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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