4RFN

Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48

Summary for 4RFN

• Entry DOI: 10.2210/pdb4rfn/pdb
• Related: 4H8W 4JZW 4RFE 4RFO
• Descriptor: HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, ... (5 entities in total)
• Functional Keywords: hiv-1 gp120, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 183325.55

Authors

Gohain, N.,Tolbert, W.D.,Pazgier, M. (deposition date: 2014-09-26, release date: 2015-07-15, Last modification date: 2023-09-20)

• Primary citation: Gohain, N.,Tolbert, W.D.,Acharya, P.,Yu, L.,Liu, T.,Zhao, P.,Orlandi, C.,Visciano, M.L.,Kamin-Lewis, R.,Sajadi, M.M.,Martin, L.,Robinson, J.E.,Kwong, P.D.,DeVico, A.L.,Ray, K.,Lewis, G.K.,Pazgier, M.; Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.; J.Virol., 89:8840-8854, 2015; PubMed: 26085162; DOI: 10.1128/JVI.01232-15

Experimental method

X-RAY DIFFRACTION (3.21 Å)