4RFN
Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48
Summary for 4RFN
Entry DOI | 10.2210/pdb4rfn/pdb |
Related | 4H8W 4JZW 4RFE 4RFO |
Descriptor | HIV-1 CLADE A/E 93TH057 (H375S) GP120, FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4, ... (5 entities in total) |
Functional Keywords | hiv-1 gp120, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 183325.55 |
Authors | Gohain, N.,Tolbert, W.D.,Pazgier, M. (deposition date: 2014-09-26, release date: 2015-07-15, Last modification date: 2023-09-20) |
Primary citation | Gohain, N.,Tolbert, W.D.,Acharya, P.,Yu, L.,Liu, T.,Zhao, P.,Orlandi, C.,Visciano, M.L.,Kamin-Lewis, R.,Sajadi, M.M.,Martin, L.,Robinson, J.E.,Kwong, P.D.,DeVico, A.L.,Ray, K.,Lewis, G.K.,Pazgier, M. Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. J.Virol., 89:8840-8854, 2015 Cited by PubMed: 26085162DOI: 10.1128/JVI.01232-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.21 Å) |
Structure validation
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