4RFN

Crystal structure of ADCC-potent Rhesus macaque ANTIBODY JR4 in complex with HIV-1 CLADE A/E GP120 and M48

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, A	HIV-1 CLADE A/E 93TH057 (H375S) GP120	polymer	353	39160.4	2	Pfam (PF00516) UniProt (by SIFTS) (Q0ED31) In PDB	Human immunodeficiency virus 1 (HIV-1)
2	H, B	FAB HEAVY CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4	polymer	233	24847.8	2		Macaca mulatta (rhesus macaque)
3	L, C	FAB LIGHT CHAIN OF ADCC ANTI-HIV-1 ANTIBODY JR4	polymer	216	22719.1	2		Macaca mulatta (rhesus macaque)
4	M, D	T-CELL SURFACE GLYCOPROTEIN CD4 mimetic M48	polymer	28	2944.6	2		synthetic construct
5	G, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	179343.8
Non-Polymers*	Number of molecules	18
	Total formula weight	3981.7
All*	Total formula weight	183325.6

*Water molecules are not included.