4GW4

Crystal structure of 3BNC60 Fab with P61A mutation

Summary for 4GW4

• Entry DOI: 10.2210/pdb4gw4/pdb
• Descriptor: 3BNC60 Fab Light-chain, 3BNC60 Fab Heavy-chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fwr, igg, anti hiv, gp120, hiv, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 96325.27

Authors

Diskin, R.,Fu, B.Z.,Bjorkman, P.J. (deposition date: 2012-08-31, release date: 2013-04-17, Last modification date: 2020-07-29)

• Primary citation: Klein, F.,Diskin, R.,Scheid, J.F.,Gaebler, C.,Mouquet, H.,Georgiev, I.S.,Pancera, M.,Zhou, T.,Incesu, R.B.,Fu, B.Z.,Gnanapragasam, P.N.,Oliveira, T.Y.,Seaman, M.S.,Kwong, P.D.,Bjorkman, P.J.,Nussenzweig, M.C.; Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.; Cell(Cambridge,Mass.), 153:126-138, 2013; PubMed: 23540694; DOI: 10.1016/j.cell.2013.03.018

Experimental method

X-RAY DIFFRACTION (2.65 Å)