7TTX

Crystal structure of potent neutralizing antibody 10-40 in complex with Sarbecovirus bat RaTG13 receptor-binding domain

Summary for 7TTX

• Entry DOI: 10.2210/pdb7ttx/pdb
• Descriptor: Spike glycoprotein, 1040 heavy chain, 1040 light chain, ... (4 entities in total)
• Functional Keywords: covid-19, sarbecovirus, ratg13 rbd, viral protein, spike glycoprotein, receptor binding protein, neutralizing antibody, potent, 10-40, fab, viral protein-immune system complex, viral protein/immune system
• Biological source: Bat coronavirus RaTG13; More
• Total number of polymer chains: 3
• Total formula weight: 75028.57

Authors

Reddem, E.R.,Shapiro, L. (deposition date: 2022-02-02, release date: 2022-04-27, Last modification date: 2023-10-18)

• Primary citation: Liu, L.,Iketani, S.,Guo, Y.,Reddem, E.R.,Casner, R.G.,Nair, M.S.,Yu, J.,Chan, J.F.,Wang, M.,Cerutti, G.,Li, Z.,Morano, N.C.,Castagna, C.D.,Corredor, L.,Chu, H.,Yuan, S.,Poon, V.K.,Chan, C.C.,Chen, Z.,Luo, Y.,Cunningham, M.,Chavez, A.,Yin, M.T.,Perlin, D.S.,Tsuji, M.,Yuen, K.Y.,Kwong, P.D.,Sheng, Z.,Huang, Y.,Shapiro, L.,Ho, D.D.; An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses.; Sci Transl Med, 14:eabn6859-eabn6859, 2022; PubMed: 35438546; DOI: 10.1126/scitranslmed.abn6859

Experimental method

X-RAY DIFFRACTION (2.8 Å)