4EWH
 
 | | Co-crystal structure of ACK1 with inhibitor | | Descriptor: | 6-{4-[2-(dimethylamino)ethoxy]phenyl}-N-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Activated CDC42 kinase 1 | | Authors: | Liu, J, Walker, N, Wang, Z. | | Deposit date: | 2012-04-27 | | Release date: | 2012-09-19 | | Last modified: | 2012-10-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4ERD
 | | Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 in complex with stem IV of telomerase RNA | | Descriptor: | 5'-R(P*GP*GP*UP*CP*GP*AP*CP*AP*UP*CP*UP*UP*CP*GP*GP*AP*UP*GP*GP*AP*CP*C)-3', POTASSIUM ION, Telomerase associated protein p65 | | Authors: | Singh, M, Wang, Z, Koo, B.-K, Patel, A, Cascio, D, Collins, K, Feigon, J. | | Deposit date: | 2012-04-19 | | Release date: | 2012-06-20 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.589 Å) | | Cite: | Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65.
Mol.Cell, 47, 2012
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5C01
 | | Crystal Structure of kinase | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2, ... | | Authors: | Min, X, Wang, Z, Walker, N. | | Deposit date: | 2015-06-12 | | Release date: | 2015-09-16 | | Last modified: | 2015-11-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
J.Biol.Chem., 290, 2015
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5C03
 | | Crystal Structure of kinase | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Min, X, Wang, Z, Walker, N. | | Deposit date: | 2015-06-12 | | Release date: | 2015-09-16 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
J.Biol.Chem., 290, 2015
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5CO4
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3JAV
 | | Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 1 | | Authors: | Fan, G, Baker, M.L, Wang, Z, Baker, M.R, Sinyagovskiy, P.A, Chiu, W, Ludtke, S.J, Serysheva, I.I. | | Deposit date: | 2015-06-30 | | Release date: | 2015-10-07 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Gating machinery of InsP3R channels revealed by electron cryomicroscopy.
Nature, 527, 2015
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4EYT
 | | Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 | | Descriptor: | SULFATE ION, Telomerase associated protein p65 | | Authors: | Singh, M, Wang, Z, Koo, B.-K, Patel, A, Cascio, D, Collins, K, Feigon, J. | | Deposit date: | 2012-05-01 | | Release date: | 2012-06-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65.
Mol.Cell, 47, 2012
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4L02
 | | Crystal Structure of SphK1 with inhibitor | | Descriptor: | (2R,4S)-1-[2-(4-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethyl]-2-(hydroxymethyl)piperidin-4-ol, Sphingosine kinase 1 | | Authors: | Min, X, Walker, N, Wang, Z. | | Deposit date: | 2013-05-30 | | Release date: | 2013-07-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
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4YND
 | | The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 | | Descriptor: | N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... | | Authors: | Sweis, R.F, Wang, Z, Algire, M, Arrowsmith, C.H, Brown, P.J, Chiang, G.C, Guo, J, Jakob, C.G, Kennedy, S, Li, F, Soni, N.B, Vedadi, M, Pappano, W.N. | | Deposit date: | 2015-03-09 | | Release date: | 2015-05-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Acs Med.Chem.Lett., 6, 2015
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3QKV
 | | Crystal structure of fatty acid amide hydrolase with small molecule compound | | Descriptor: | (6-bromo-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidin]-1'-yl)methanol, Fatty-acid amide hydrolase 1 | | Authors: | Min, X, Walker, N.P.C, Wang, Z. | | Deposit date: | 2011-02-01 | | Release date: | 2011-04-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QJ9
 | | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 1-{(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one, Fatty-acid amide hydrolase 1, ... | | Authors: | Min, X, Walker, N.P.C, Wang, Z. | | Deposit date: | 2011-01-28 | | Release date: | 2011-04-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
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8JQ9
 | | Novel Anti-phage System | | Descriptor: | Endonuclease GajA | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQB
 | | Structure of Gabija GajA-GajB 4:4 Complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQC
 | | Novel Anti-phage System | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8WY4
 | | GajA tetramer with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-10-30 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8X5N
 | | Tetramer Gabija with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA, Gabija protein GajB, ... | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-11-17 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8X5I
 | | tetramer Gabija with ATP (local refinement) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA, MAGNESIUM ION | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-11-17 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8X51
 | | Cryo-EM structure of Gabija GajA in complex with DNA(focused refinement) | | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*TP*T)-3'), ... | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-11-16 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8WY5
 | | Structure of Gabija GajA in complex with DNA | | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*T)-3'), ... | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-10-30 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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2KGG
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3O7R
 | | Crystal structure of Ru(p-cymene)/apo-H49AFr | | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, Ferritin light chain, ... | | Authors: | Takezawa, Y, Bockmann, P, Sugi, N, Wang, Z, Abe, S, Murakami, T, Hikage, T, Erker, G, Watanabe, Y, Kitagawa, S, Ueno, T. | | Deposit date: | 2010-07-31 | | Release date: | 2011-04-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Incorporation of organometallic Ru complexes into apo-ferritin cage.
J.CHEM.SOC.,DALTON TRANS., 40, 2011
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3O7S
 | | Crystal structure of Ru(p-cymene)/apo-Fr | | Descriptor: | 1,2-ETHANEDIOL, 1-methyl-4-(1-methylethyl)benzene, CADMIUM ION, ... | | Authors: | Takezawa, Y, Bockmann, P, Sugi, N, Wang, Z, Abe, S, Murakami, T, Hikage, T, Erker, G, Watanabe, Y, Kitagawa, S, Ueno, T. | | Deposit date: | 2010-07-31 | | Release date: | 2011-04-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Incorporation of organometallic Ru complexes into apo-ferritin cage.
J.Chem.Soc.,Dalton Trans., 40, 2011
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3P66
 | | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | | Descriptor: | GOLD 3+ ION, Lysozyme C | | Authors: | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | | Deposit date: | 2010-10-11 | | Release date: | 2011-02-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
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2KGI
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3P4Z
 | | Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme | | Descriptor: | CHLORIDE ION, GOLD 3+ ION, GOLD ION, ... | | Authors: | Wei, H, Wang, Z, Zhang, J, House, S, Gao, Y.-G, Yang, L, Robinson, H, Tan, L.H, Xing, H, Hou, C, Robertson, I.M, Zuo, J.-M, Lu, Y. | | Deposit date: | 2010-10-07 | | Release date: | 2011-02-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
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