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5WI9

Crystal structure of KL with an agonist Fab

Summary for 5WI9
Entry DOI10.2210/pdb5wi9/pdb
DescriptorBeta-klotho, 39F7 Fab light chain, 39F7 Fab heavy chain, ... (8 entities in total)
Functional Keywordsbeta-klotho, scaffold protein, fibroblast growth factors, structural protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight205534.16
Authors
Johnstone, S.,Min, X.,Wang, Z. (deposition date: 2017-07-18, release date: 2018-07-25, Last modification date: 2020-07-29)
Primary citationMin, X.,Weiszmann, J.,Johnstone, S.,Wang, W.,Yu, X.,Romanow, W.,Thibault, S.,Li, Y.,Wang, Z.
Agonistic beta-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions.
J. Biol. Chem., 293:14678-14688, 2018
Cited by
PubMed: 30068552
DOI: 10.1074/jbc.RA118.004343
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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