5WI9
Crystal structure of KL with an agonist Fab
Summary for 5WI9
Entry DOI | 10.2210/pdb5wi9/pdb |
Descriptor | Beta-klotho, 39F7 Fab light chain, 39F7 Fab heavy chain, ... (8 entities in total) |
Functional Keywords | beta-klotho, scaffold protein, fibroblast growth factors, structural protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 205534.16 |
Authors | Johnstone, S.,Min, X.,Wang, Z. (deposition date: 2017-07-18, release date: 2018-07-25, Last modification date: 2020-07-29) |
Primary citation | Min, X.,Weiszmann, J.,Johnstone, S.,Wang, W.,Yu, X.,Romanow, W.,Thibault, S.,Li, Y.,Wang, Z. Agonistic beta-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions. J. Biol. Chem., 293:14678-14688, 2018 Cited by PubMed: 30068552DOI: 10.1074/jbc.RA118.004343 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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