5WI9
Crystal structure of KL with an agonist Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Beta-klotho | polymer | 470 | 54465.4 | 2 | UniProt (Q86Z14) Pfam (PF00232) In PDB | Homo sapiens (Human) | BetaKlotho,Klotho beta-like protein |
2 | L, E | 39F7 Fab light chain | polymer | 215 | 23240.7 | 2 | Homo sapiens | ||
3 | H, F | 39F7 Fab heavy chain | polymer | 225 | 24111.1 | 2 | Homo sapiens | ||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | A, B, H | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | A, L | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
8 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B: 52 - 508 (UniProt: Q86Z14)
PDB | External Database | Details |
---|---|---|
Glu 509 | - | expression tag |
Asn 510 | - | expression tag |
Leu 511 | - | expression tag |
Tyr 512 | - | expression tag |
Phe 513 | - | expression tag |
Gln 514 | - | expression tag |
Gly 515 | - | expression tag |
His 516 | - | expression tag |
His 517 | - | expression tag |
His 518 | - | expression tag |
His 519 | - | expression tag |
His 520 | - | expression tag |
His 521 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 203634.3 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 1899.9 | |
All* | Total formula weight | 205534.2 |