5WI9

Crystal structure of KL with an agonist Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Beta-klotho	polymer	470	54465.4	2	UniProt (Q86Z14) Pfam (PF00232) In PDB	Homo sapiens (Human)	BetaKlotho,Klotho beta-like protein
2	L, E	39F7 Fab light chain	polymer	215	23240.7	2		Homo sapiens
3	H, F	39F7 Fab heavy chain	polymer	225	24111.1	2		Homo sapiens
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	A, B, H	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
6	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	A, L	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
8		water	water		18.0	156	Chemie (HOH)

Sequence modifications

A, B: 52 - 508 (UniProt: Q86Z14)

PDB	External Database	Details
Glu 509	-	expression tag
Asn 510	-	expression tag
Leu 511	-	expression tag
Tyr 512	-	expression tag
Phe 513	-	expression tag
Gln 514	-	expression tag
Gly 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	203634.3
Non-Polymers*	Number of molecules	15
	Total formula weight	1899.9
All*	Total formula weight	205534.2

*Water molecules are not included.