6V3F

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Summary for 6V3F

Entry DOI	10.2210/pdb6v3f/pdb
EMDB information	21035
Descriptor	NPC1-like intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	cholesterol, transporter, tunnel, sterol, intestine, ezetimibe, sterol-sensing domain, lipid transport
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	151936.53
Authors	Huang, C.S.,Yu, X.,Min, X.,Wang, Z. (deposition date: 2019-11-25, release date: 2020-07-01, Last modification date: 2024-10-23)
Primary citation	Huang, C.S.,Yu, X.,Fordstrom, P.,Choi, K.,Chung, B.C.,Roh, S.H.,Chiu, W.,Zhou, M.,Min, X.,Wang, Z. Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition Sci Adv, 6:eabb1989-, 2020 Cited by DOI: 10.1126/sciadv.abb1989 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation